Browsing Waterloo Research by Author "Zeng, Leilei"
Now showing items 1-6 of 6
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Cohort study design for illness-death processes with disease status under intermittent observation
Moon, Nathalie C.; Zeng, Leilei; Cook, Richard J. (Taylor & Francis, 2019-12-12)Cohort studies are routinely conducted to learn about the incidence or progression rates of chronic diseases. The illness-death model offers a natural framework for joint consideration of non-fatal events in the semi-competing ... -
Design of cancer trials based on progression-free survival with intermittent assessment
Zeng, Leilei; Cook, Richard J.; Lee, Ker-Ai (Wiley, 2018-03-26)Therapeutic advances in cancer mean that it is now impractical to performed phase III randomized trials evaluating experimental treatments on the basis of overall survival. As a result, the composite endpoint of progression-free ... -
Mitigating bias from intermittent measurement of time-dependent covariates in failure time analysis
Jiang, Shu; Cook, Richard J.; Zeng, Leilei (Wiley, 2020-06-15)Cox regression models are routinely fitted to examine the association between time-dependent markers and a failure time when analyzing data from clinical registries. Typically, the marker values are measured periodically ... -
Multistate analysis from cross-sectional and auxiliary samples
Zeng, Leilei; Cook, Richard J.; Lee, Jooyoung (Wiley, 2020-02-20)Epidemiological studies routinely involve cross‐sectional sampling of a population comprised of individuals progressing through life history processes. We consider features of a cross‐sectional sample in terms of the ... -
A Multistate Model for Bivariate Interval-Censored Failure Time Data
Cook, Richard J.; Zeng, Leilei; Lee, Ker-Ai (Wiley, 2008-12)Interval-censored life-history data arise when the events of interest are only detectable at periodic assessments. When interest lies in the occurrence of two such events, bivariate-interval censored event time data are ... -
Tracing studies in cohorts with attrition: Selection models for efficient sampling
Moon, Nathalie C.; Zeng, Leilei; Cook, Richard J. (Wiley, 2018-07-10)Cohort studies of chronic diseases involve recruitment and longitudinal followup of affected individuals with a view to studying the effect of risk factors on disease progression and death. When the time to withdrawal from ...