Browsing Optometry and Vision Science by Author "Jones, Lyndon W."
Now showing items 1-20 of 30
-
Acetic and Acrylic Acid Molecular Imprinted Model Silicone Hydrogel Materials for Ciprofloxacin-HCl Delivery
Hui, Alex; Sheardown, Heather; Jones, Lyndon W. (Multidisciplinary Digital Publishing Institute, 2012-01-02)Contact lenses, as an alternative drug delivery vehicle for the eye compared to eye drops, are desirable due to potential advantages in dosing regimen, bioavailability and patient tolerance/compliance. The challenge has ... -
Atomic force microscopy and Langmuir–Blodgett monolayer technique to assess contact lens deposits and human meibum extracts
Hagedorn, Sarah; Drolle, Elizabeth; Lorentz, Holly; Srinivasan, Sruthi; Leonenko, Zoya; Jones, Lyndon W. (Elsevier, 2015-07)Purpose: The purpose of this exploratory study was to investigate the differences in meibomian gland secretions, contact lens (CL) lipid extracts, and CL surface topography between participants with and without meibomian ... -
Branching and size of CTAB-coated gold nanostars control the colorimetric detection of bacteria
Verma, Mohit S.; Chen, Paul Z.; Jones, Lyndon W.; Gu, Frank X. (Royal Society of Chemistry, 2014)Rapid detection of pathogenic bacteria is challenging because conventional methods require long incubation times. Nanoparticles have the potential to detect pathogens before they can cause an infection. Gold nanostars have ... -
Comparison of meibomian gland dropout using two infrared imaging devices
Wong, Stephanie; Srinivasan, Sruthi; Murphy, Paul J.; Jones, Lyndon W. (Elsevier, 2018-11-07)Purpose To measure the degree of meibomian gland (MG) dropout in the lower eyelid determined by analysis of images obtained from the LipiView II (LVII) and the Keratograph 5M (K5M). Methods The inferior eyelid of each ... -
Composition of incubation solution impacts in vitro protein uptake to silicone hydrogel contact lenses
Jadi, Salsabeel; Heynen, Miriam L.; Luensmann, Doerte; Jones, Lyndon W. (Molecular Vision, 2012-02-04)Purpose: To determine the impact of incubation solution composition on protein deposition to silicone hydrogel (SH) contact lenses using a simplistic and a complex model of the tear film. Methods: Three SH materials – ... -
Contact lens physical properties and lipid deposition in a novel characterized artificial tear solution
Lorentz, Holly; Heynen, Miriam L.; Kay, Lise M. M.; Dominici, Claudia Y.; Khan, Warda; Ng, Wendy W. S.; Jones, Lyndon W. (Molecular Vision, 2011-12-24)Purpose: To characterize various properties of a physiologically-relevant artificial tear solution (ATS) containing a range of tear film components within a complex salt solution, and to measure contact lens parameters and ... -
Controlling “chemical nose” biosensor characteristics by modulating gold nanoparticle shape and concentration
Verma, Mohit S.; Chen, Paul Z.; Jones, Lyndon W.; Gu, Frank X. (Elsevier, 2015-09)Conventional lock-and-key biosensors often only detect a single pathogen because they incorporate biomolecules with high specificity. “Chemical nose” biosensors are overcoming this limitation and identifying multiple ... -
Corneal Swelling with Cosmetic etafilcon A Lenses versus No Lens Wear:
Moezzi, Amir Mahmoud; Varikooty, Jalaiah; Schulze, Marc; Ngo, William; Lorenz, Kathrine O.; Boree, Danielle; Jones, Lyndon W. (Wolters & Kluwer, 2016-06)Purpose: To determine if the use of pigments or adding polyvinyl pyrrolidone during the fabrication of 1-DAY ACUVUE DEFINE (AD) brand contact lenses impacts open-eye corneal swelling compared with no lens wear (NLW). ... -
Development of an In Vitro Ocular Platform to Test Contact Lenses
Phan, Chau-Minh; Walther, Hendrik; Gao, Huayi; Rossy, Jordan; Subbaraman, Lakshman N.; Jones, Lyndon W. (Journal of Visualized Experiments, 2016-06-04)Currently, in vitro evaluations of contact lenses (CLs) for drug delivery are typically performed in large volume vials,1-6 which fail to mimic physiological tear volumes.7 The traditional model also lacks the natural tear ... -
Extended Latanoprost Release from Commercial Contact Lenses: In Vitro Studies Using Corneal Models
Mohammadi, Saman; Jones, Lyndon W.; Gorbet, Maud (Public Library of Science, 2014-10-09)In this study, we compared, for the first time, the release of a 432 kDa prostaglandin analogue drug, Latanoprost, from commercially available contact lenses using in vitro models with corneal epithelial cells. Conventional ... -
Historical overview of imaging the meibomian glands
Ngo, William; Srinivasan, Sruthi; Jones, Lyndon W. (Elsevier, 2013-01)Growing knowledge of the role of the meibomian glands in dry eye disease and contact lens discomfort has resulted in a surge of interest in visualizing these glands within the eyelids. This manuscript provides an overview ... -
Impression Cytology of the Lid Wiper Area
Jones, Lyndon W.; Subbaraman, Lakshman N.; Muntz, Alex; van Doorn, Kevin (Journal of Visualized Experiments, 2016-09-08)Few reports on the cellular anatomy of the lid wiper (LW) area of the inner eyelid exist and only one report makes use of cytological methods. The optimization of a method of collecting, staining and imaging cells from the ... -
In Vitro and In Vivo Evaluation of Novel Ciprofloxacin-Releasing Silicone Hydrogel Contact Lenses
Hui, Alex; Willcox, Mark D. P.; Jones, Lyndon W. (Association for Research in Vision and Ophthalmology, 2014-08-08)Purpose.: The purpose of this study was to evaluate ciprofloxacin-releasing silicone hydrogel contact lens materials in vitro and in vivo for the treatment of microbial keratitis. Methods.: Model silicone hydrogel contact ... -
In vitro ultraviolet–induced damage in human corneal, lens, and retinal pigment epithelial cells
Youn, Hyun-Yi; McCanna, David J.; Sivak, Jacob G.; Jones, Lyndon W. (Molecular Vision, 2011-01-21)Purpose: The purpose was to develop suitable in vitro methods to detect ocular epithelial cell damage when exposed to UV radiation, in an effort to evaluate UV-absorbing ophthalmic biomaterials.Methods: Human corneal ... -
Infrared Imaging of Meibomian Glands and Evaluation of the Lipid Layer in Sjogren's Syndrome Patients and Nondry Eye Controls
Menzies, K. L.; Srinivasan, Sruthi; Prokopich, C. L.; Jones, Lyndon W. (Association for Research in Vision and Ophthalmology, 2015-05-02)Purpose.: The purpose of this study was to evaluate meibomian gland dropout and lipid layer thickness (LLT) in patients with and without Sjögren's syndrome dry eye (SS). Methods.: We recruited 11 participants with SS ... -
Inhibition of Defocus-Induced Myopia in Chickens
Woods, Jill; Guthrie, Sarah E.; Keir, Nancy; Dillehay, Sally; Tyson, Mark; Griffin, Richard; Choh, Vivian Cheng-Pei; Fonn, Desmond; Jones, Lyndon W.; Irving, Elizabeth (Association for Research in Vision and Ophthalmology, 2013-04-12)Purpose.: To determine the effect of wearing a lens with a unique peripheral optical design on the development and progression of defocus-induced myopia in newly hatched chickens.Methods.: Eighty-five newly hatched chickens ... -
Insights to Using Contact Lenses for Drug Delivery
Phan, Chau-Minh; Walther, Hendrik; Gao, Huayi; Rossy, Jordan; Subbaraman, Lakshman N.; Jones, Lyndon W. (Omics International, 2013)There has been considerable interest in the potential application of contact lenses for ocular drug delivery. This short communication provides an overview of the challenges faced by delivering drugs using contact lenses, ... -
Quantification of MUCIN 1, cell surface associated and MUCIN16, cell surface associated proteins in tears and conjunctival epithelial cells collected from postmenopausal women
Srinivasan, Sruthi; Heynen, Miriam L.; Martell, Elizabeth; Ritter, Robert; Jones, Lyndon W.; Senchyna, Michelle (Molecular Vision, 2013-05-04)Purpose: To quantify the expression of mucin 1, cell surface associated (MUC1) and mucin 16, cell surface associated (MUC16) proteins and messenger ribonucleic acid (mRNA) in a cohort of postmenopausal women (PMW), to ... -
Release of Ciprofloxacin and Moxifloxacin From Daily Disposable Contact Lenses From an In Vitro Eye Model
Bajgrowicz-Cieslak, Magdalena; Phan, Chau-Minh; Subbaraman, Lakshman N.; Jones, Lyndon W. (Association for Research in Vision and Ophthalmology, 2015-10-04)Purpose.: To analyze the release of two fluoroquinolones, ciprofloxacin and moxifloxacin, from conventional hydrogel (CH) and silicone hydrogel (SH) daily disposable contact lenses (CLs), comparing release from a fixed-volume ... -
Release of Ciprofloxacin-HCl and Dexamethasone Phosphate by Hyaluronic Acid Containing Silicone Polymers
Nguyen, Darrene; Hui, Alex; Weeks, Andrea; Heynen, Miriam L.; Joyce, Elizabeth; Sheardown, Heather; Jones, Lyndon W. (Multidisciplinary Digital Publishing Institute, 2012-04-19)The purpose of this study was to determine the effect of the covalent incorporation of hyaluronic acid (HA) into conventional hydrogel and hydrogels containing silicone as models for contact lens materials on the uptake ...