Browsing Chemistry by Type "Master Thesis"
Now showing items 1-20 of 291
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3D printing of soft hydrogels incorporating functional nanomaterials
(University of Waterloo, 2017-01-10)Tissue engineering (TE) scaffolds are required to closely mimic the human body environment to enable the study of cell behavior in vitro and allow the fabrication of artificial tissue constructs. The scaffolds should possess ... -
Action Mechanism and Structural Studies on the Lipopeptide Antibiotic Daptomycin
(University of Waterloo, 2019-07-02)Daptomycin (dap) is calcium-dependent lipopeptide antibiotic that is used clinically to treat systemic infections caused by Gram-positive pathogens. It is thought that dap brings about its antimicrobial effect by binding ... -
Advanced research on Lithium-Sulfur battery : studies of lithium polysulfides.
(University of Waterloo, 2013-10-03)This thesis was devised as a fundamental study of the Li-S system by the use of 7Li Magic Angle Spinning (MAS) Nuclear Magnetic Resonance (NMR), X-ray Absorption Near- Edge Structure (XANES), and Non-Resonant Inelastic ... -
Application of matrix compatible solid phase microextraction (SPME) coatings for the analysis in complex food matrices
(University of Waterloo, 2020-01-06)In recent years, studies regarding food analysis have increased due to the globalization of food trade as well as concerns about the safety and traceability of food commodities. In this regard, the field of food analysis ... -
Application of Microwave‐Assisted Technologies for the Analysis of Chlorinated Solvents in Rock Samples
(University of Waterloo, 2012-01-25)It has been a direction for research of late to examine the extraction process of volatile organic compounds (VOCs) from solid matrices. Removal of VOCs from a solid matrix can be challenging due to the nature of the analyte ... -
Application of Squaric acid to The Preparation of Bioactive Compounds
(University of Waterloo, 2008-08-28)Nucleosides and nucleoside analogues exhibit a broad spectrum of biological activities including antiviral, anticancer, antibacterial and antiparasitic activities, which generally result from their ability to inhibit ... -
Applications of Membrane Extraction with a Sorbent Interface
(University of Waterloo, 2009-01-22)Membrane extraction with a sorbent interface (MESI) is a sample preparation technique with a rugged and simple design allowing for solvent-free, on-line performance. When coupled to gas chromatography (GC), MESI is an ... -
Approaches to the Inhibition of Class II Fructose-1,6-Bisphosphate Aldolase
(University of Waterloo, 2009-05-22)Fructose-1,6-bisphosphate (FBP) aldolase (E.C. 4.1.2.13) catalyzes the reversible aldol condensation of dihydroxyacetonephosphate (DHAP) and glyceraldehyde-3-phosphate (G3P) in glycolysis, gluconeogenesis and the Calvin ... -
Aptamer-Based Detection of Caffeine and Theophylline Through Utilization of Gold Nanoparticles and Graphene Oxide
(University of Waterloo, 2023-04-26)The caffeine and theophylline aptamers were used in tandem with gold nanoparticles and graphene oxide to study potential methods for small molecule detection. The AuNP approach is a label-free approach, and the graphene ... -
Arborescent Polypeptides for the Targeted and Controlled Release of Drugs
(University of Waterloo, 2022-01-20)Amphiphilic block copolymer micelles are commonly used as drug delivery agents, but these micelle structures tend to dissociate upon dilution. In contrast, arborescent copolymers are highly branched unimolecular micelles ... -
Arborescent Polystyrene-graft-Polyisoprene Copolymers as Polymer Processing Additives
(University of Waterloo, 2009-05-01)Some commodity polymers such as linear low density polyethylene (LLDPE) suffer from melt defects including sharkskin, cyclic melt fracture, and gross melt fracture during processing. The occurrence of these defects sets ... -
Associations between Oil Additives in Base Oils Probed by Pyrene Excimer Fluorescence
(University of Waterloo, 2017-10-23)A recently developed method based on pyrene excimer fluorescence was used to probe the interactions of important polymeric oil additives. First, three ethylene-propylene (EP) copolymers representative of viscosity index ... -
Asymmetric Alkenylation of Enones and Other α,β-Unsaturated Carbonyl Derivatives Using Chiral 3,3′-Disubstituted Binaphthols and Boronates
(University of Waterloo, 2009-05-22)Various α,β-unsaturated carbonyl compounds and derivatives were explored in order to expand the range of substrates for the 1,4-addition of alkenylboronates using 3,3′-disubstituted binaphthols. Enones 2.60 were examined ... -
Asymmetric Conjugate Addition of Arylboronates to α,β-unsaturated Enones Catalyzed by Substituted Binaphthols
(University of Waterloo, 2009-10-01)Conjugate addition reactions are one of the most widely used carbon-carbon bond forming reactions in organic synthesis. This reaction can form a chiral center and can be used for the synthesis of structurally complex ... -
Asymmetric Conjugate Addition of Boronates to N-Acylimines and β-Silyl-α,β-unsaturated Ketones Catalyzed by 3,3'-Disubstituted Binaphthols
(University of Waterloo, 2009-01-23)In order to extend the scope of asymmetric conjugate alkenylation catalyzed by 3,3′-disubstituted binaphthols, two classes of compounds were examined. Asymmetric 1,4-addition of alkenylboronates onto N-acylimines was ... -
Asymmetric Conjugate Additions of Boronates to α,β-Unsaturated Trifluoromethyl Ketones and Strategies Towards Asymmetric Conjugate Additions of N-Boc-Pyrrole Boronic Acid
(University of Waterloo, 2016-08-24)An important class of organic molecules are those that contain fluorine. Fluorinated molecules have found widespread use in medicinal chemistry, as well as in agrochemicals. This is due to the ability of fluorine to act ... -
Binding of Au3+ Ions by Polyadenine DNA
(University of Waterloo, 2020-09-02)Interactions between DNA and metal ions are important for many applications such as metal sensing, therapeutics and nanotechnology. Many studies have already been published on these topics. DNA can bind metal ions via its ... -
Biochemical Characterization and Optimization of RNA Aptamers Bound to Hoechst Dye Derivatives
(University of Waterloo, 2023-08-09)Ribonucleic acid (RNA) aptamers are single-stranded nucleic acids that are typically selected through a process known as Systematic Evolution of Ligands by EXponential Enrichment (SELEX). These oligonucleotides can bind ... -
Biochemical Characterization of Fluorophore-Binding Nucleic Acids
(University of Waterloo, 2022-09-27)Aptamers, single stranded RNA or DNA that bind to target ligands with high affinity and specificity, have a wide range of applications, from therapeutics to biosensing, which makes biochemical characterization of the utmost ... -
Biochemistry in Bacterioferritin
(University of Waterloo, 2006)Bacterioferritin, an iron storage protein having a 24-subunit quaternary structure, was used as a model for the study of host-guest interactions and guest encapsulation, making use of its spherical cage-like structure. ...