Browsing Chemistry by Author "Zhang, TianHua"
Now showing items 1-7 of 7
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Cardiolipin Prevents Membrane Translocation and Permeabilization by Daptomycin
Zhang, TianHua; Muraih, Jawad K.; Tishbi, Nasim; Herskowitz, Jennifer; Victor, Rachel L.; Silverman, Jared; Uwumarenogie, Stephanie; Taylor, Scott D.; Palmer, Michael; Mintzer, Evan (American Society for Biochemistry and Molecular Biology, 2014-04-25)Daptomycin is an acidic lipopeptide antibiotic that, in the presence of calcium, forms oligomeric pores on membranes containing phosphatidylglycerol. It is clinically used against various Gram-positive bacteria such as ... -
Daptomycin forms cation- and size-selective pores in model membranes
Zhang, TianHua; Muraih, Jawad K.; MacCormick, Ben; Silverman, Jared; Palmer, Michael (Elsevier, 2014-10)Daptomycin is a lipopeptide antibiotic that is used clinically to treat severe infections caused by Gram-positive bacteria. Its bactericidal action involves the calcium-dependent binding to membranes containing ... -
Daptomycin: Mechanism of Action and Bacterial Resistance
Zhang, TianHua (University of Waterloo, 2015-02-25)Daptomycin is an important lipopeptide antibiotic used for treating severe infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus ... -
Identification of functional regions of streptococcus agalactiae CAMP factor
Zhang, TianHua (University of Waterloo, 2008-09-26)Streptococcus agalactiae CAMP factor is a protein exotoxin that contains 226 amino acid residues and forms oligomeric pores on susceptible cell membranes and liposomes. In this study, fragments of CAMP factor were created ... -
Membrane binding and oligomer formation by the calcium-dependent lipopeptide antibiotic A54145: a quantitative study with pyrene excimer fluorescence
Zhang, TianHua; Taylor, Scott D.; Palmer, Michael; Duhamel, Jean (Elsevier, 2016-09-20)A54145 is a lipopeptide antibiotic related to daptomycin that permeabilizes bacterial cell membranes. Its action requires both calcium and phosphatidylglycerol in the target membrane, and it is accompanied by the formation ... -
Mutual inhibition through hybrid oligomer formation of daptomycin and the semisynthetic lipopeptide antibiotic CB-182,462
Zhang, TianHua; Mintzer, Evan; Tishbi, Nasim; Desert, Celine; Silverman, Jared; Taylor, Scott D.; Palmer, Michael (Elsevier, 2013-02)Daptomycin is a clinically important lipopeptide antibiotic that kills Gram-positive bacteria through membrane depolarization. Its activity requires calcium and the presence of phosphatidylglycerol in the target membrane. ... -
Two successive calcium-dependent transitions mediate membrane binding and oligomerization of daptomycin and the related antibiotic A54145
Taylor, Robert; Butt, Khalida; Scott, Bradley; Zhang, TianHua; Muraih, Jawad K.; Mintzer, Evan; Taylor, Scott D.; Palmer, Michael (Elsevier, 2016-09)Daptomycin and A54145 are homologous lipopeptide antibiotics that permeabilize the cell membranes of Gram-positive bacteria. Membrane permeabilization depends on the presence of both phosphatidylglycerol (PG) and calcium, ...