Science (Faculty of): Recent submissions
Now showing items 1-20 of 3025
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Line-Field Spectral Domain Optical Coherence Tomography: Design and Biomedical Applications
(University of Waterloo, 2024-05-10)Corneal diseases such as keratoconus and Fuchs' dystrophy lead to the dysfunction of the cornea, which can result in vision loss. Early-stage detection at the cellular level provides the opportunity for treatment that slows ... -
Differential Gene Expression Analysis using Resampling
(University of Waterloo, 2024-05-09)The primary objective in high-throughput sequencing is to identify differentially expressed genes, which provides substantial information of gene expression and regulation. A persistent challenge in this field is the bias ... -
Metatranscriptomic analysis of pediatric acute sinusitis: pathogen detection and host response profiling
(University of Waterloo, 2024-05-08)Acute sinusitis (AS) is the fifth leading cause of antibiotic prescriptions in children. Distinguishing bacterial AS from common viral upper respiratory infections in children is crucial to prevent unnecessary antibiotic ... -
Computational modeling of bacterial chromosome organization: macromolecular crowding, chain heterogeneity, and chain cross-linking
(University of Waterloo, 2024-04-30)Chromosome organization is integral to life, as it plays a pivotal role in maintaining the integrity and functionality of genomic materials, as well as facilitating the transcription, replication, and transmission of genetic ... -
The Effect of Freezing on the Elution of PVA from Contact Lenses
(University of Waterloo, 2024-04-30)Contact lenses are widely used, with over 140 million wearers globally. Wearing contact lenses can cause symptoms of discomfort and dryness, which affect nearly half of all wearers. To address this concern, this thesis ... -
Synthesis of Deuterated Benzene for a Circular Deuterium Economy
(University of Waterloo, 2024-04-30)Deuterium is an important natural isotope; its unique properties can impart significant effects on molecules with emerging applications across electronics and medicinal industries. Aromatic hydrocarbons or arenes are one ... -
Advancing Linear-Scaling Techniques in Computation of Exchange Matrices in Mean-Field and Cluster-in-Molecule Calculations
(University of Waterloo, 2024-04-30)Quantum chemistry faces ongoing challenges in developing methods that combine efficiency with accuracy, especially for large molecular systems. The Cluster-in-Molecule (CiM) technique, integrated with Coupled Cluster theory ... -
Pyrene Excimer Formation: A Tool to Study Macromolecular Conformations in Solution
(University of Waterloo, 2024-04-26)The current view for fluorescence collisional quenching (FCQ) experiments is that no quantitative information can be retrieved from macromolecules containing more than a single dye-quencher pair attached at two specific ... -
Metabolic engineering strategies for biomanufacturing of chemicals using Yarrowia lipolytica and Escherichia coli
(University of Waterloo, 2024-04-24)This dissertation advances metabolic engineering by optimizing the genetic and metabolic capabilities of Yarrowia lipolytica and Escherichia coli to enhance their applications in biotechnology. It focuses on improving Y. ... -
Evaluation of the Potential Impacts of Submerging the Oxidized Tailings and Adding a Cover Layer at Mine Principale
(University of Waterloo, 2024-04-24)Oxidation of sulfide minerals generates acid and forms various secondary phases including Fe(III) (oxy)hydroxide phases, jarosite, and gypsum, which can attenuate hazardous metal(loid)s by precipitation, co-precipitation, ... -
Chlorophyll-a Mapping in a Large Lake Using Remote Sensing Imagery: A Case Study of Western Lake Ontario
(University of Waterloo, 2024-04-23)Western Lake Ontario (WLO) and Hamilton Harbour (HH) experience significant eutrophication challenges. Despite an overall decrease in the limiting nutrient phosphorus (P) inputs, recurrent nuisance (Cladophora) and ... -
Glacial Dispersion at the Canadian Malartic Gold Deposit
(University of Waterloo, 2024-04-19)A novel drift prospecting approach detected components from previously established bedrock footprints at the world-class Canadian Malartic gold deposit within the site’s surrounding Quaternary sediments. The measured glacial ... -
Correlation Functions of Heavy Operators in AdS/CFT
(University of Waterloo, 2024-04-15)In this thesis we investigate the holographic dual description of correlation functions of heavy operators in conformal field theory. These heavy operators have scaling dimension that scales with the CFT central charge in ... -
Structural and Biochemical Insights into Previously Uncharacterized Activity of Nucleotide-Dependent Phosphoenolpyruvate Carboxykinases
(University of Waterloo, 2024-04-08)Phosphoenolpyruvate carboxykinase (PEPCK) enzymes are central to glucose metabolism, with their main role in catalyzing one of the first steps of gluconeogenesis. In addition to its primary role, PEPCK is also involved, ... -
Evolution of the Laurentide Ice Sheet in north-central Ontario from subglacial sediments
(University of Waterloo, 2024-03-12)Till stratigraphic analysis of 10 sediment bluffs near Ogoki Post in the Hudson and James Bay Lowlands. -
Arylbenzamide and Arylcarboxamide Derivatives as Modulators of Amyloid-Beta Aggregation
(University of Waterloo, 2024-03-11)Alzheimer’s disease (AD) is a complex neurodegenerative disease with increasing incidence and prevalence globally. The current AD therapies based on small molecules offer only symptomatic relief and are not curative ... -
Environmental DNA barcoding as a method of amphibian species detection compared to conventional monitoring techniques in southern Ontario vernal pools
(University of Waterloo, 2024-03-06)Ongoing monitoring is vital for the conservation of amphibian species and is conducted through conventional auditory and visual surveys. A molecular method, termed environmental DNA (eDNA) barcoding, may offer a more ... -
Development and biomedical applications of solid phase micro-extraction (bio-SPME) chemical biopsy devices
(University of Waterloo, 2024-02-22)Micro-sampling is a vital component in modern diagnostics and personalized medicine. In vivo SPME is a novel branch of biomedical applications of SPME (Bio-SPME) that offers unique advantages complementary to existing ... -
Development of III-V Semiconductor Surface Quantum Wells for Hybrid Superconducting Device Applications
(University of Waterloo, 2024-02-20)This thesis concerns the materials development of both InSb/InAlSb and InAs/AlGaSb surface quantum wells: Two of the most promising platforms for the study of proximity-induced superconductivity in semiconductors with ... -
Controlling Exciton Polarization in Transition Metal Doped Indium Oxide Nanocrystals
(University of Waterloo, 2024-02-20)The simultaneous manipulation of electronic charge and spin in dilute magnetic semiconductors (DMSs) doped with transition metal ions has been long considered a holy grail for advancing spintronics and quantum information ...