Browsing Science (Faculty of) by Type "Doctoral Thesis"
Now showing items 1-20 of 767
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5-HT7 Receptor Neuroprotection against Excitotoxicity in the Hippocampus
(University of Waterloo, 2014-04-11)Introduction and Objectives: The PDGFβ receptor and its ligand, PDGF-BB, are expressed throughout the central nervous system (CNS), including the hippocampas. Several reports confirm that PDGFβ receptors are neuroprotective ... -
The adaptive elements of disparity vergence: Dynamics and directional asymmetries.
(University of Waterloo, 2018-04-24)Vergence eye movements alter the angle between the two visual axes, creating changes in binocular fixation distance. They are primarily stimulated by retinal image disparities, but can also be driven by inputs from ocular ... -
Adhesion of Two Cylindrical Particles to a Soft Membrane Tube
(University of Waterloo, 2012-09-26)The interaction of nanoparticles with biological systems, especially interactions with cell membranes, has been a subject of active research due to its numerous applications in many areas of soft-matter and biological ... -
Adnectin Solubility and Dynamics
(University of Waterloo, 2019-10-28)Rapid growth of the global market for monoclonal antibodies (mAbs) has generated considerable interest in the development of alternative molecules that facilitate rapid discovery and manufacturing, while replicating the ... -
Advanced Electrodes and Electrolytes For Long-Lived and High-Energy-Density Lithium-Sulfur Batteries
(University of Waterloo, 2017-05-16)The increasing demand on renewable but intermittent energy and the need for electrified transportation place great emphasis on energy storage. Lithium-sulfur (Li-S) batteries are promising systems due to the high theoretical ... -
Advanced Separation Techniques in the Analysis of Environmental Pollutants
(University of Waterloo, 2012-04-30)Recent developments in chromatographic supports and instrumentation for liquid chromatography are enabling rapid and highly efficient separations. Various analytical strategies have been recently proposed, for example the ... -
Advances in Biamperometry with Applications in Ocular Toxicology
(University of Waterloo, 2013-10-02)This thesis presents advances in biamperometry, together with applications cyclic biamperometry, in in vitro ocular cytotoxicity assessment. For the cytotoxicity/viability assessment, cultured human corneal epithelial cells ... -
Advances in Multidimensional Chromatography
(University of Waterloo, 2012-07-23)Comprehensive two-dimensional gas chromatography (GC×GC) is among the most powerful methods used to separate complex samples. Two columns of different selectivities are coupled in series through a special interface ... -
Advances in solid-phase microextraction as sample preparation method for food analysis.
(University of Waterloo, 2015-02-25)Within all steps involved in the analytical process, sample preparation is considered the most time-consuming step. Therefore, substantial efforts have focused on the search for automated sample preparation strategies that ... -
Advances in the density matrix renormalization group method for use in quantum chemistry
(University of Waterloo, 2008-05-01)Despite the success of modern quantum chemistry in predicting properties of organic molecules, the treatment of inorganic systems, which have many close lying states, remains out of quantitative reach for current methods. ... -
Adventures in Holography
(University of Waterloo, 2014-07-11)In this thesis, inspired by the holographic theories, we study a variety of interesting problems in gravity, condensed matter and cosmology. First, we explore the entanglement entropy of a general region in a theory of ... -
Aggregation of Amyotrophic Lateral Sclerosis-Associated Cu/Zn Superoxide Dismutase
(University of Waterloo, 2010-05-21)Amyotrophic lateral sclerosis (ALS) is a devastating, progressive, and fatal neurodegenerative disease. Despite the fact that ALS is the most common motor neuron disease in adulthood, there is no effective treatment for ... -
Algorithms for quantum molecular dynamics: from matrix product states to path integrals
(University of Waterloo, 2021-01-13)This thesis describes several novel approaches in quantum molecular dynamics for obtaining properties of molecular systems in different regimes. We investigate ground state properties of chains of linear rotors with ... -
An ALMA View of Molecular Gas in Brightest Cluster Galaxies
(University of Waterloo, 2018-09-25)In this thesis I use ALMA observations to map the distribution and kinematics of molecular gas in the brightest cluster galaxies of three galaxy clusters: 2A0335+096, RXJ0821+0752, and RXCJ1504-0248. The goal is to understand ... -
Alternative splicing of Lymnaea Cav3 and NALCN ion channel genes serves to alter biophysical properties, membrane expression, and ion selectivity
(University of Waterloo, 2012-08-30)Evidence is presented that Lymnaea contains homologues for mammalian Cav3 and NALCN 4-domain ion channels, which retain key amino acid sequence motifs that differentiate these channels from other 4-domain types. Molecular ... -
Ammonia-oxidizing archaea in engineered biofiltration systems
(University of Waterloo, 2016-12-21)Ammonia is a nitrogenous metabolic waste product that is produced by all animal life. High concentrations of ammonia are toxic to animals and may result in algal blooms and eutrophication in aquatic environments. To prevent ... -
Amplitudes in the Spin Foam Approach to Quantum Gravity
(University of Waterloo, 2017-07-31)In this thesis, we study a Spin Foam model for 4D Riemannian quantum gravity, and propose a new way of imposing the simplicity constraints that uses the recently developed holomorphic representation. Rather than imposing ... -
Analysis of heat shock protein 30 gene expression and function in Xenopus laevis A6 kidney epithelial cells
(University of Waterloo, 2014-04-30)Heat shock proteins (HSPs) are molecular chaperones that assist in protein synthesis, folding and degradation and prevent stress-induced protein aggregation. The present study examined the pattern of accumulation of HSP30 ... -
Analysis of plasma chemokines and circulating tumour cells in colorectal and breast cancer patient peripheral blood
(University of Waterloo, 2020-01-22)Circulating tumour cells (CTCs) provide a prognostic value in solid tumours including colorectal and breast. Enumeration of tumour cells from blood is becoming a common practice in informing prognosis and may guide therapy ... -
Antifungal ocular drug delivery via contact lenses using a novel in vitro eye model
(University of Waterloo, 2016-04-21)Purpose: The purpose of this thesis was to evaluate the potential of contact lenses (CLs) as an antifungal drug delivery device, and to develop an in vitro eye model to test thereof. Methods: The first three chapters ...