Browsing Science (Faculty of) by Supervisor "Jones, Lyndon"
Now showing items 1-16 of 16
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Antifungal ocular drug delivery via contact lenses using a novel in vitro eye model
(University of Waterloo, 2016-04-21)Purpose: The purpose of this thesis was to evaluate the potential of contact lenses (CLs) as an antifungal drug delivery device, and to develop an in vitro eye model to test thereof. Methods: The first three chapters ... -
Aspects of Corneal Fluorescein Staining
(University of Waterloo, 2019-04-25)PURPOSE Evaluating the cornea for epithelial fluorescein staining is a key element of the ocular examination of contact lens wearers and people with dry eye disease. It has long been viewed as a method of visualizing a ... -
Cellular changes at the lid margin
(University of Waterloo, 2017-11-28)PURPOSE: The hypothesis underlying this thesis is that CL wear, lid wiper epitheliopathy (LWE), and symptoms of dryness and discomfort may be manifest as cellular changes of the lid marginal epithelium, as a result of ... -
Contact Lenses and Tear Film Lipids.
(University of Waterloo, 2017-12-20)Introduction Lipids are essential tear components that aid the stability of the tear film (TF) to protect it from excess evaporation. The composition, conformation, and function of TF lipids are jeopardized by external ... -
Contemporary Diagnosis and Management of Dry Eye
(University of Waterloo, 2016-08-31)Introduction Dry eye (DE) disease is characterized by symptoms including, but not limited to, ocular stinging, burning, and tearing. The symptoms can range from being mildly irritating, to severely debilitating and ... -
Development of an in vitro eye model to better represent in vivo physiological conditions
(University of Waterloo, 2021-06-23)Purpose The purpose of this thesis was to optimize a novel in vitro blink model, the OcuBlink, to best mimic the physiological characteristics of the human eye. By improving this in vitro model, the results from in vitro ... -
Examination of Contact Lenses and Dry Eye Using Evaporimetry
(University of Waterloo, 2022-01-14)Purpose: Evaporimetry is a non-invasive technique used to assess the stability of the tear film. The test measures the rate of tear evaporation, and has been used to investigate dry eye, contact lenses, and the efficacy ... -
Fabrication of an enzyme responsive biomaterial for the treatment of recurrent corneal erosion
(University of Waterloo, 2023-04-11)Purpose: Recurrent corneal erosion (RCE) arising from the loss of superficial corneal epithelial cells causes tremendous ocular pain affecting one’s productivity and quality of life. RCE was traditionally treated with eye ... -
Fabrication of microfluidic chip using 3D printing for ocular cell studies
(University of Waterloo, 2023-09-25)Purpose: This thesis aimed to create a polydimethylsiloxane (PDMS) microfluidic chip utilizing low-cost commercial 3D printers and to integrate human corneal epithelial cells (HCEC) into the fabricated chip. Methods: The ... -
Immobilization of Gold Nanoparticles for Colourimetric and Ratiometric Refractive Index Sensing
(University of Waterloo, 2019-12-12)The development of refractive index sensors is an expanding field of research, with applications in fields including medical diagnostics, food safety and public health. Nanotechnology has become widely implemented in various ... -
In Vitro Release of Inflammatory Cytokines from Contact Lens Materials
(University of Waterloo, 2020-12-22)The upregulation of inflammatory mediators in the tear film during contact lens wear indicates that lens wear may induce an inflammatory response on the ocular surface. Previous research has investigated the relationship ... -
Interaction of Tear Inflammatory Markers with Contact Lens Materials
(University of Waterloo, 2020-01-28)Biomaterials are natural or synthetic materials that come into contact with biological tissue. Contact lenses are the most commonly used biomaterials, being worn by an estimated 140 million people worldwide. While contact ... -
The Phenotype of Tear Neutrophils and Their Role in Ocular Homeostasis and Inflammation
(University of Waterloo, 2023-07-31)Introduction: Neutrophils (polymorphonuclear neutrophils, PMNs) are part of the innate immune system with potent killing mechanisms against pathogens. Although the anterior segment of the eye has a unique characteristic, ... -
Protocol development for reliable isolation of tear-film neutrophils and in vitro functionality testing
(University of Waterloo, 2019-09-19)During prolonged eye closure, such as during sleep, leukocytes are recruited to the ocular surface, with polymorphonuclear neutrophils (PMNs) representing the largest population. PMNs are essential inflammatory cells ... -
Studies on the Optimization of Neuropeptides Detection in the Human Tear Film
(University of Waterloo, 2020-05-13)Introduction: Dry Eye Disease (DED) stems from a disruption of the homeostasis of the tear film (TF), a thin layer of fluid covering the ocular surface. The TF consists of numerous constituents that include proteins, ... -
Uptake and release of preservatives from soft contact lens materials
(University of Waterloo, 2022-01-13)Purpose: The purpose of this thesis was to examine the uptake and release of myristamidopropyl dimethylamine (MAPD) and polyhexamethylene biguanide (PHMB) from soft contact lens material using various in vitro models to ...