Browsing Science (Faculty of) by Subject "evolution"
Now showing items 1-6 of 6
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Alternative splicing of Lymnaea Cav3 and NALCN ion channel genes serves to alter biophysical properties, membrane expression, and ion selectivity
(University of Waterloo, 2012-08-30)Evidence is presented that Lymnaea contains homologues for mammalian Cav3 and NALCN 4-domain ion channels, which retain key amino acid sequence motifs that differentiate these channels from other 4-domain types. Molecular ... -
Catalytic Potential and Ligand Binding Properties of the Malachite Green RNA Aptamer
(University of Waterloo, 2008-09-18)The malachite green aptamer was originally engineered for binding specificity to malachite green (MG). The environment inside the aptamer’s electronegative binding pocket was previously harnessed to catalyze an ester ... -
Computational Design of Protein Structure and Prediction of Ligand Binding
(University of Waterloo, 2016-08-23)Proteins perform a tremendous array of finely-tuned functions which are not only critical in living organisms, but can be used for industrial and medical purposes. The ability to rationally design these molecular machines ... -
A Data Mining Approach for Detecting Evolutionary Divergence in Transcriptomic Data
(University of Waterloo, 2019-11-19)It has become common to produce genome sequences for organisms of scientific or popular interest. Although these genome projects provide insight into the gene and protein complements of a species including their evolutionary ... -
From Peptides to Proteins: Exploring Modular Evolution Through the Beta-Trefoil Fold
(University of Waterloo, 2010-01-25)Understanding the origin of protein folds, and the mechanism by which evolution has generated them, is a critically important step on a path towards rational protein design. Modifying existing proteins and designing our ... -
The modulation of leguminous plant ethylene levels by symbiotic rhizobia played a role in the evolution of the nodulation process
(Elsevier, 2018-12)Ethylene plays an important role in regulating the rhizobial nodulation process. Consequently, numerous strains of rhizobia possess the ability to decrease plant ethylene levels by the expression of the enzyme 1-aminocyc ...