Browsing Science (Faculty of) by Subject "cisplatin"
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Physiologically based Pharmacokinetic (PBPK) Modelling of Cisplatin in Rats and Humans
(University of Waterloo, 2019-10-17)The physiologically based pharmacokinetic (PBPK) modelling has been accepted as one of the most effective mechanistic techniques to analyze pharmacokinetics (PK) of drugs in the drug development process. Its effectiveness ... -
Study of a Molecular Promoter for Enhancing Cisplatin Cancer Chemotherapy
(University of Waterloo, 2010-05-25)Cisplatin is one of the most widely used chemotherapeutic anti-cancer drugs due to its ability to effectively damage DNA and cause cell death. Despite this, cisplatin still suffers from two main drawbacks: toxicity and ...