Browsing Science (Faculty of) by Subject "DDK"
Now showing items 1-2 of 2
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The characterization of Dbf4 interactions and roles in genome replication and stability in Saccharomyces cerevisiae
(University of Waterloo, 2020-03-05)Dbf4-dependent kinase (DDK) is a complex composed of the Cdc7 kinase and its regulatory subunit, Dbf4. Initiation of eukaryotic DNA replication requires phosphorylation of Mcm2-7 helicase by DDK. Due to its essential role ... -
Characterizing the Associations and Roles of DDK and Mcm2-7 DNA Replication Proteins in Saccharomyces Cerevisiae
(University of Waterloo, 2014-05-21)The essential cell cycle kinase Dbf4/Cdc7 (DDK) triggers DNA replication through phosphorylation of the Mcm2-7 helicase at replication origins. Prior work has implicated various Mcm2-7 subunits as targets of DDK, however ...