Browsing Science (Faculty of) by Title
Now showing items 2718-2737 of 3042
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Synthesis and Chemistry of Kinamycins and Related Antibiotics
(University of Waterloo, 2010-06-17)The kinamycin antitumor antibiotics, discovered in Japan in the early 1970s as secondary metabolites of the soil bacterium Streptomyces murayamaensis, were at first believed to be derivatives of the N-cyanobenzo[b]carbazole ... -
Synthesis and Investigation on Phase Transition of BaTiO3 and Cr3+-Doped BaTiO3 Nanocrystals
(University of Waterloo, 2009-10-01)Various sizes of BaTiO3 and Cr3+-doped BaTiO3 nanocrystals were synthesized through hydrothermal and solvothermal methods. The applied solvents water, ethanol and benzyl alcohol lead to nanoparticles with average sizes of ... -
Synthesis and Reactivity of Aryl(trifluoromethyl)diazomethane Compounds
(University of Waterloo, 2020-10-26)Fluorine has a prominent role in organic chemistry and the pharmaceutical industry due to the unique properties it imparts. Naturally, trifluoromethyl groups (CF3) share similar qualities and many methods have been developed ... -
Synthesis and Self-Assembly of Metal Carbonyl Building Blocks for Aqueous Colloids with Aggregation-Induced Functions
(University of Waterloo, 2017-04-06)Metal carbonyl complexes (MCCs) are potentially useful for a range of biomedical applications, including cell imaging and bioassay. However, the poor solubility and stability of MCCs in water remain obstacles to their use ... -
Synthesis and Self-Assembly of Metal Carbonyl Organometallic Macromolecules Prepared via Migration Insertion Polymerization
(University of Waterloo, 2016-05-18)Migration insertion polymerization (MIP) has been developed for the synthesis of air-stable metal carbonyl polymers. CpFe(CO)₂(CH₂)₃PPh₂ (FpP) was synthesized as a monomer. The solution polymerization of FpP at a monomer ... -
Synthesis and Solution Behaviour of CpFe(CO)(PPh3)[CO(CH2)3N(CH3)2] (FpC3NMe2)
(University of Waterloo, 2017-09-18)Metal carbonyl (MC) colloids in water have a wide range of biomedical applications. The Fp-acyl (Fp: CpFe(CO)2) derivatives are one kind of MC molecules that can be synthesized through migration insertion reaction (MIR). ... -
Synthesis and Study of the Cyclic Lipopeptide Antibiotics Daptomycin and A54145
(University of Waterloo, 2022-09-21)Daptomycin (dap) is a clinical antibiotic used to treat infections with multi-drug resistant Gram-positive bacteria. Despite nearly 20 years of clinical use, the action mechanism of this important peptide is not fully ... -
Synthesis and Study of the Cyclic Lipopeptide Antibiotics Paenibacterin and Daptomycin
(University of Waterloo, 2021-09-23)Cyclic lipopeptides present a rich source of antimicrobial compounds with diverse modes of action. Paenibacterin is a cyclic lipopeptide antibiotic produced by Paenibacillus thaminolyticus that exhibits activity against a ... -
The Synthesis of 3-Vinylindolines by the Palladium-Catalyzed Intramolecular Allylic Alkylation of Cinnamyl Acetates and the Synthesis of Polyphenolic 4-Aryl-3,4-dihydrocoumarins by Domino Friedel-Crafts Reactions
(University of Waterloo, 2018-10-24)Historically, the alkylation of allylic acetates with non-stabilized C(sp3) nucleophiles has been challenging. The metal-catalyzed alkylation of allylic acetates and carbonates with organotin and organoboron reagents has ... -
Synthesis of Arborescent Amphiphilic Copolymers
(University of Waterloo, 2013-01-25)Living anionic polymerization techniques were applied to the synthesis of arborescent (dendritic) well-defined graft polymers having core-shell morphologies, with a hydrophobic core and a hydrophilic shell. Cycles of ... -
Synthesis of Arborescent Copolymers Based on Poly(γ-benzyl L-glutamate)
(University of Waterloo, 2013-04-26)The synthesis of arborescent poly(gamma-benzyl L-glutamate) (PBG) molecules was achieved through successive grafting reactions of linear PBG chains. These linear PBG building blocks were obtained by the ring-opening ... -
Synthesis of Arborescent Polybutadiene
(University of Waterloo, 2012-08-10)Arborescent polymers are characterized by a tree-like architecture and a high branching functionality. This type of polymer can be synthesized by different techniques, but the ‘grafting onto’ method is attractive because ... -
Synthesis of carboxylated derivatives of poly(isobutylene-co-isoprene) by azide–alkyne “click” chemistry
(Springer, 2018-09-28)The synthesis of carboxylated derivatives of poly(isobutylene-co-isoprene) (isobutylene–isoprene rubber, IIR) with substitution levels ranging from 1 to 4 mol% and different spacer lengths was accomplished through azide–alkyne ... -
Synthesis of Cyclodextrin-Complexed Metal Carbonyl Polymers
(University of Waterloo, 2016-08-10)The synthesis of metal carbonyl (MC) polymers has been explored for decades, but well-defined and well-characterized MC polymers are rarely reported mainly due to the chemical instability of MC complexes. To address this ... -
Synthesis of Deuterated Benzene for a Circular Deuterium Economy
(University of Waterloo, 2024-04-30)Deuterium is an important natural isotope; its unique properties can impart significant effects on molecules with emerging applications across electronics and medicinal industries. Aromatic hydrocarbons or arenes are one ... -
Synthesis of Inhibitors of Steroid Sulfatase and Towards the Synthesis of a Chiral Electrophilic Fluorinating Reagent
(University of Waterloo, 2007-02-02)Steroid sulfatase (STS) catalyzes the desulfation of sulfated steroids such as estrone sulfate to the corresponding steroid such as estrone. Inhibitors of STS are believed to have potential for treating estrogen-dependent ... -
Synthesis of Molecularly Defined Conjugated Oligomers and Polymers through Dehydrative Coupling
(University of Waterloo, 2019-08-21)The development of scalable methods for the synthesis of conjugated materials remains among the most important aspects for their integration into devices at a commercial level. Drawing inspiration from nature as well as ... -
Synthesis of Multiply Deuterated Cephalosporins
(University of Waterloo, 2014-12-12)Antibiotics are one of the greatest accomplishments in the field of science. They have been extensively used since the time of their discovery. Amongst all the antibiotics, the -lactam class of antibiotics have been the ... -
Synthesis of New Magnetic Nanocomposite Materials for Data Storage
(University of Waterloo, 2012-08-09)The confinement of magnetic nanoparticles (Prussian blue analogues (PBAs) has been achieved using mesostructured silica as a matrix. The PBAs have the general formula AxMy[M'(CN)n]z, where A is an alkali metal cation; M: ... -
Synthesis of Nucleoside Polyphosphates and their Conjugates
(University of Waterloo, 2014-01-02)Nucleoside polyphosphates and their conjugates, such as nucleoside triphosphates, nucleoside tetraphosphates, sugar nucleotides, dinucleoside pyro- and higher order polyphosphates, 2’,3’-cyclic nucleoside monophosphates, ...