Browsing Science (Faculty of) by Author "Doyle, Colleen"
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A Refined Method for Quantitation of Divalent Metal Ions in Metalloproteins and Local Stability and Conformational Heterogeneity of Amyotrophic Lateral Sclerosis-Associated Cu, Zn Superoxide Dismutase
Doyle, Colleen (University of Waterloo, 2014-05-13)Amyotrophic lateral sclerosis (ALS) is a devastating and progressive disease that results in selective death of motor neurons in the cortex, brain stem and spinal cord. ALS is the most common adult onset motor neuron disease ... -
Spectrophotometric method for simultaneous measurement of zinc and copper in metalloproteins using 4-(2-pyridylazo)resorcinol
Doyle, Colleen M.; Naser, Dalia; Bauman, Heather A.; Rumfeldt, Jessica; Meiering, Elizabeth M. (Elsevier, 2019-08-15)Bound metals are observed in a great many natural proteins, where they perform diverse roles in determining protein folding, stability and function. Due to the broad impact of bound metals on biophysical and biochemical ...