Browsing Kinesiology and Health Sciences by Subject "Calcium"
Now showing items 1-3 of 3
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The Effects of a Calcineurin Inhibitor on Muscle Fibre Type and the Pathology of Centronuclear Myopathy in PlnOE Mice
(University of Waterloo, 2017-01-27)The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump is responsible for pumping calcium from the cytosol back into the lumen of the sarcoplasmic reticulum post contraction. SERCA activity can be reduced by an inhibitory ... -
Examining the Effect of Parvalbumin Overexpression on the Development of Centronuclear Myopathy in Phospholamban Overexpressing Mice
(University of Waterloo, 2022-05-18)Within the myofibre, the sarco(endo)plasmic reticulum (SR) Ca2+ ATPase (SERCA) has an essential role in regulating intracellular Ca2+ concentrations ([Ca2+]i) by pumping Ca2+ into the SR. There are several known regulators ... -
The Role of Sarcolipin in Calcium Handling and Obesity
(University of Waterloo, 2010-05-19)Sarcolipin (SLN), a small molecular weight, hydrophobic protein found in skeletal muscle, is a known regulator of sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pumps. Earlier in vitro reconstitution experiments have ...