Browsing Health (Faculty of) by Subject "glutathione"
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Influence of acute and chronic glutathione manipulations on coronary vascular resistance and endothelium dependent dilation in isolated perfused rat hearts
(University of Waterloo, 2011-01-25)Glutathione (GSH), a 3-amino acid compound is ubiquitously expressed in eukaryotic cells and is the most abundant low molecular weight thiol. The importance of GSH is highlighted by its multitude of effects. Within the ... -
Mechanisms of over-active endothelium-derived contracting factor signaling causing common carotid artery endothelial vasomotor dysfunction in hypertension and aging
(University of Waterloo, 2011-03-09)Background and Purpose: The endothelium is a single-cell layer positioned at the blood-vascular wall interface, where in response to blood-borne signals and hemodynamic forces, endothelial cells act as central regulators ... -
The role of glutathione depletion in skeletal muscle apoptotic signalling in young and old rats
(University of Waterloo, 2010-09-27)There is substantial evidence that oxidative stress causes negative outcomes in many cell and tissue types. This is especially true of skeletal muscle, as it is continually subjected to various sources of reactive oxygen ...