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dc.contributor.authorTayyari, Faryan 16:52:37 (GMT)
dc.description.abstractIntroduction: Diabetic retinopathy (DR) is a major source of visual loss in the world, including North America. A number of hyperglycemia-related pathways have been associated with DR onset and progression. Disturbances in the retinal vasculature appear to play a vital role in DR, resulting in biochemical and functional vascular changes. Therefore, this study investigated retinal blood oxygen saturation and angiogenic and inflammatory biomarkers in DR. Methods: Chapter 3 and 5: FD-OCT Doppler blood flow was non-invasively measured using a prototype system based on the RTVue (Optovue Inc., USA). A minimum of six separate FD-OCT Doppler measurements was acquired. Chapter 4, 5, 7: Non-invasive hyperspectral retinal (HR) imaging was acquired in participants with mild-to-moderate NPDR and age-matched controls. For each subject, six repeated HRC images were acquired at wavelengths of 586 and 605nm. Results: Chapter3: The individual COV medians for retinal blood flow were 7.5% and 9.2% for young and elderly subjects, respectively. The group mean CORs for retinal blood flow for young participants were 6.4µl/min and for elderly subjects were 10.5µl/min. Chapter 4: Retinal blood oxygen saturation in the arterioles of healthy controls was 92.97±1.6%, and in the venules was 55.90±4.8%. Retinal blood oxygen saturation for diabetic subjects with NPDR was significantly higher at 94.65±2.2% (p=0.015) in the arterioles and 64.13±4.3% (p<0.001) in the venules. Chapter 5: Total retinal blood flow was significantly lower in NPDR when compared to controls (42.66 vs 32.97; p=0.004). There was no relationship between total retinal blood flow and venular oxygen saturation (r=0.2). Chapter 6: Angiopoietin 2, IL-8, HGF was significantly higher in NPDR patients than in control patients (p=0.005, p=0.034, p=0.018, respectively) and EGF was significantly lower in NPDR patients when compared to controls (p=0.025). Chapter 7: The study demonstrated a correlation between retinal blood oxygen saturation and Ang 2, HGF and EGF but did not find any correlation for IL-8, TGF-β even though these biomarkers were significantly higher in the diabetic group. Conclusions: Chapter 3: Doppler OCT gave consistent and repeatable blood flow measurements within retinal venules in normal subjects. Chapter 4: A higher blood oxygen saturation could be the result of less oxygen consumtion due to cell death. Chapter 5: There is no correlation between retinal blood flow and retinal blood oxygen saturation. Chapter 6: Further investigation of Ang 2, HGF, IL-8, EGF, TGF-β could be used to better understand the pathophysiology of DR. Chapter 7: The result of this study revealed a relationship between the biomarkers that might result in cell death and higher retinal blood oxygen saturation.en
dc.publisherUniversity of Waterlooen
dc.subjectRetinal Oxygen Saturationen
dc.subjectRetinal Blood Flowen
dc.subjectInflammatory and Angiogenic Biomarkersen
dc.subjectDiabetic Retinopathyen
dc.titleRetinal Blood Oxygen Saturation and Angiogenic and Inflammatory Biomarkers in Type 2 Diabetesen
dc.typeDoctoral Thesisen
dc.subject.programVision Scienceen
dc.description.embargoterms1 yearen of Optometry and Vision Scienceen
uws-etd.degreeDoctor of Philosophyen

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