dc.contributor.author | Adams, Meaghan S. | |
dc.contributor.author | Andrew, Danielle | |
dc.contributor.author | Staines, W. Richard | |
dc.date.accessioned | 2024-05-27 20:08:02 (GMT) | |
dc.date.available | 2024-05-27 20:08:02 (GMT) | |
dc.date.issued | 2019-10 | |
dc.identifier.uri | https://doi.org/10.1007/s00221-019-05633-9 | |
dc.identifier.uri | http://hdl.handle.net/10012/20618 | |
dc.description | This is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00221-019-05633-9. | en |
dc.description.abstract | Patients with lesions of the prefrontal cortex (PFC) show increased distractibility and impairments in inhibiting cortical
responses to irrelevant stimuli. This study was designed to test the role of the PFC in the early modality-specific modulation
of event-related potentials (ERPs) generated during a sensory selection task. The task required participants to make a
scaled motor response to the amplitudes of visual and tactile stimuli presented individually or concurrently. Task relevance
was manipulated and continuous theta burst stimulation (cTBS) was used to transiently inhibit PFC activity to test the contribution
of the PFC to modulation of sensory gating. Electroencephalography (EEG) was collected from participants both
before and after cTBS was applied. The somatosensory-evoked N70 ERP was shown to be modulated by task relevance
before but not after cTBS was applied to the PFC, and downregulating PFC activity through the use of cTBS abolished any
relevancy differences in N70 amplitude. In conclusion, this study demonstrated that early modality-specific changes in cortical
somatosensory processing are modulated by attention, and that this effect is subserved by prefrontal cortical activity. | en |
dc.description.sponsorship | NSERC | en |
dc.language.iso | en | en |
dc.publisher | Springer | en |
dc.relation.ispartofseries | Experimental Brain Research;237(10) | |
dc.subject | continuous theta burst stimulation | en |
dc.subject | prefrontal cortex | en |
dc.subject | task relevance | en |
dc.subject | attentional gating | en |
dc.title | The contribution of the prefrontal cortex to relevancy‑based gating of visual and tactile stimuli. | en |
dc.type | Article | en |
dcterms.bibliographicCitation | Adams, M. S., Andrew, D., & Staines, W. R. (2019). The contribution of the prefrontal cortex to relevancy-based gating of visual and tactile stimuli. Experimental Brain Research, 237(10), 2747–2759. https://doi.org/10.1007/s00221-019-05633-9 | en |
uws.contributor.affiliation1 | Faculty of Health | en |
uws.contributor.affiliation2 | Kinesiology and Health Sciences | en |
uws.typeOfResource | Text | en |
uws.peerReviewStatus | Reviewed | en |
uws.scholarLevel | Faculty | en |
uws.scholarLevel | Graduate | en |