Browsing University of Waterloo by Subject "a54145"
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Mutual inhibition through hybrid oligomer formation of daptomycin and the semisynthetic lipopeptide antibiotic CB-182,462
(Elsevier, 2013-02)Daptomycin is a clinically important lipopeptide antibiotic that kills Gram-positive bacteria through membrane depolarization. Its activity requires calcium and the presence of phosphatidylglycerol in the target membrane. ... -
Synthesis and Study of the Cyclic Lipopeptide Antibiotics Daptomycin and A54145
(University of Waterloo, 2022-09-21)Daptomycin (dap) is a clinical antibiotic used to treat infections with multi-drug resistant Gram-positive bacteria. Despite nearly 20 years of clinical use, the action mechanism of this important peptide is not fully ...