Choh, Vivian Cheng-PeiGurdita, AkshayTan, BingyaoPrasad, Ratna C.Bizheva, KostadinkaJoos, Karen M.2017-02-222017-02-222016-04-01https://doi.org/10.1167/iovs.15-18770http://hdl.handle.net/10012/11328This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed. Original publication: Choh, V., Gurdita, A., Tan, B., Prasad, R. C., Bizheva, K., & Joos, K. M. (2016). Short-Term Moderately Elevated Intraocular Pressure Is Associated With Elevated Scotopic Electroretinogram ResponsesShort-Term Elevated IOP and Scotopic ERG Responses. Investigative Ophthalmology & Visual Science, 57(4), 2140–2151. https://doi.org/10.1167/iovs.15-18770Moderately elevated intraocular pressure (IOP) is a risk factor for open-angle glaucoma. Some patients suffer glaucoma despite clinically measured normal IOPs. Fluctuations in IOP may have a significant role since IOPs are higher during sleep and inversion activities. Controlled transient elevations of IOPs in rats over time lead to optic nerve structural changes that are similar to the early changes observed in constant chronic models of glaucoma. Because early intervention decreases glaucoma progression, this study was done to determine if early physiological changes to the retina could be detected with noninvasive electrophysiological and optical imaging tests during moderately elevated IOP.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Eye Anatomy and DisordersGlaucomaRetinaVisual NeuroscienceRetinal ImagingArticle