Chen, Zelin2023-09-282024-01-272023-09-282023-09-22http://hdl.handle.net/10012/19979Enhanced error monitoring, as reflected in increased amplitude of the error-related negativity (ERN) ERP component, has been suggested to be a vulnerability neuro-marker of anxiety disorders. However, the association between an enhanced ERN amplitude and increased anxiety levels in the nonclinical population have been inconsistent. In a sample of 82 adults, we examined the association between anxiety and the ERN with different analytical methods (mass-univariate statistics and conventional analyses), self-reported anxiety scales (STAI and STICSA), and trial numbers (all correct trials and equal numbers of correct and error trials). Both the conventional and mass-univariate analyses demonstrated a robust enhancement of the ERN and Pe relative to the correct-ERPs. However, the mass-univariate approach additionally unveiled a wider array of electrodes and a longer duration of involvement in this error enhancement. There was no consistent moderation of the findings by trial numbers, analyses, and anxiety scales. Across the analytic methods, the results showed a lack of consistent correlation between trait anxiety and error-related ERPs. The present results suggest a lack of enhancement of error monitoring by anxious traits in individuals with sub- clinical anxiety and those with clinical anxiety but without a clinical diagnosis. Importantly, the absence of such correlation questions the validity of the ERN as a neural marker for anxiety disorders. Future studies that investigate neuro-markers of anxiety may explore alternative neural signatures and task designs and employ robust statistics to provide a more comprehensive understanding of anxiety vulnerability.enMaster Thesis