Nicola, WiltenNjap, FelixFerguson, KatieSkinner, FrancesCampbell, Sue Ann2017-09-212017-09-212014-07-21http://dx.doi.org/10.1186/1471-2202-15-S1-O3http://hdl.handle.net/10012/12428Large networks of integrate-and-fire (IF) model neurons are often used to simulate and study the behaviour of biologically realistic networks. However, to fully study the large network behaviour requires an exploration of large regions of a multidimensional parameter space. Such exploration is generally not feasible with large network models, due to the computational time required to simulate a network with biologically significant size. To circumvent these difficulties we use a mean-field approach, based on the work of [1]. We consider a sparsely coupled, excitatory network of 10,000 Izhikevich model neurons [2], with Destexhe-type synapses [3]. The cellular models were fit to hippocampal CA1 pyramidal neurons and have heterogeneous applied currents with a normal distribution. We derived a mean-field system for the network which consists of differential equations for the mean of the adaptation current and the synaptic conductance. As CA1 is an area that displays prominent theta oscillations [4], we used the mean-field system to study how the frequency of bursting depends on various model parameters. Figure 1A shows an example study. These studies were successful in guiding numerical simulations of the large network. When parameter values determined from the mean-field analysis are used in a large network simulation, bursting of the predicted frequency occurs.enAttribution 4.0 InternationalConference Presentation