Babu, Raiju JacobClavagnier, Simon R.Bobier, WilliamThompson, BenjaminHess, Robert F.2017-02-222017-02-222013-10https://doi.org/10.1167/iovs.14-13969http://hdl.handle.net/10012/11327This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed. Original publication: Babu, R. J., Clavagnier, S. R., Bobier, W., Thompson, B., & Hess, R. F. (2013). The Regional Extent of Suppression: Strabismics Versus Nonstrabismics. Investigative Opthalmology & Visual Science, 54(10), 6585. https://doi.org/10.1167/iovs.12-11314Purpose.: Evidence is accumulating that suppression may be the cause of amblyopia rather than a secondary consequence of mismatched retinal images. For example, treatment interventions that target suppression may lead to better binocular and monocular outcomes. Furthermore, it has recently been demonstrated that the measurement of suppression may have prognostic value for patching therapy. For these reasons, the measurement of suppression in the clinic needs to be improved beyond the methods that are currently available, which provide a binary outcome. Methods.: We describe a novel quantitative method for measuring the regional extent of suppression that is suitable for clinical use. The method involves a dichoptic perceptual matching procedure at multiple visual field locations. We compare a group of normal controls (mean age: 28 ± 5 years); a group with strabismic amblyopia (four with microesotropia, five with esotropia, and one with exotropia; mean age: 35 ± 10 years); and a group with nonstrabismic anisometropic amblyopia (mean age: 33 ± 12 years). Results.: The extent and magnitude of suppression was similar for observers with strabismic and nonstrabismic amblyopia. Suppression was strongest within the central field and extended throughout the 20° field that we measured. Conclusions.: Suppression extends throughout the central visual field in both strabismic and anisometropic forms of amblyopia. The strongest suppression occurs within the region of the visual field corresponding to the fovea of the fixing eye.enAttribution-NonCommercial-NoDerivatives 4.0 InternationalAmblyopiaInterocular suppressionStrabismusCentral visionArticle