Browsing Waterloo Research by Subject "Phosphatidylglycerol"
Now showing items 1-3 of 3
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Cardiolipin Prevents Membrane Translocation and Permeabilization by Daptomycin
(American Society for Biochemistry and Molecular Biology, 2014-04-25)Daptomycin is an acidic lipopeptide antibiotic that, in the presence of calcium, forms oligomeric pores on membranes containing phosphatidylglycerol. It is clinically used against various Gram-positive bacteria such as ... -
Characterization of daptomycin oligomerization with perylene excimer fluorescence: Stoichiometric binding of phosphatidylglycerol triggers oligomer formation
(Elsevier, 2012-03)Daptomycin is a lipopeptide antibiotic that binds to and depolarizes bacterial cell membranes. Its antibacterial activity requires calcium and correlates with the content of phosphatidylglycerol in the target membrane. ... -
Mechanistic studies on the effect of membrane lipid acyl chain composition on daptomycin pore formation
(Elsevier, 2018-11-01)Daptomycin is a lipopeptide antibiotic that binds and permeabilizes the cell membranes of Gram-positive bacteria. Membrane permeabilization requires both calcium and phosphatidylglycerol (PG) in the target membrane, and ...