Browsing Waterloo Research by Subject "multistate model"
Now showing items 1-4 of 4
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Design of cancer trials based on progression-free survival with intermittent assessment
(Wiley, 2018-03-26)Therapeutic advances in cancer mean that it is now impractical to performed phase III randomized trials evaluating experimental treatments on the basis of overall survival. As a result, the composite endpoint of progression-free ... -
The Design of Intervention Trials Involving Recurrent and Terminal Events
(Springer, 2013)Clinical trials are often designed to assess the effect of therapeutic interventions on the incidence of recurrent events in the presence of a dependent terminal event such as death. Statistical methods based on multistate ... -
A new perspective on loss to follow-up in failure time and life history studies
(Wiley, 2019-07-24)A framework is proposed for the joint modeling of life history and loss to follow-up (LTF) processes in cohort studies. This framework provides a basis for discussing independence conditions for LTF and censoring and ... -
Score tests based on a finite mixture model of Markov processes under intermittent observation
(Wiley, 2019-07-20)A mixture model is described, which accommodates different Markov processes governing disease progression in a finite set of latent classes. We give special attention to the setting in which individuals are examined ...