Browsing Waterloo Research by Author "Da Costa, Jason B."

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Structure and Thermodynamics of Drug-RNA Aptamer Interactions

Da Costa, Jason B.; Dieckmann, Thorsten (Bentham Science Publishers, 2013-03-01)

This mini-review will provide an overview on the recent studies of structure and thermodynamics of RNA aptamers that target drug molecules. These aptamers are studied to provide insight into RNA drug interactions. This ...
Thermodynamics and Kinetics of Adaptive Binding in the Malachite Green RNA Aptamer

Da Costa, Jason B.; Andreiev, Aurelia I.; Dieckmann, Thorsten (American Chemical Society, 2013-09-24)

Adaptive binding, the ability of molecules to fold themselves around the structure of a ligand and thereby incorporating it into their three-dimensional fold, is a key feature of most RNA aptamers. The malachite green ...