Browsing Waterloo Research by Author "Vazin, Mahsa"
Now showing items 1-7 of 7
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Biochemical Characterization of a Lanthanide-Dependent DNAzyme with Normal and Phosphorothioate-Modified Substrates
Vazin, Mahsa; Huang, Po-Jung Jimmy; Matuszek, Zaneta; Liu, Juewen (American Chemical Society, 2015-10-06)A trivalent lanthanide (Ln3+)-dependent RNA-cleaving DNAzyme, Ce13d, was recently isolated via in vitro selection. Ce13d is active in the presence of all Ln3+ ions. Via introduction of a single phosphorothioate (PS) ... -
Cr3+ Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis
Zhou, Wenhu; Yu, Tianmeng; Vazin, Mahsa; Ding, Jinsong; Liu, Juewen (American Chemical Society, 2017-06-07)The interaction between chromium ions and DNA is of great interest in inorganic chemistry, toxicology, and analytical chemistry. Most previous studies focused on in situ reduction of Cr(VI), producing Cr3+ for DNA binding. ... -
Desulfurization Activated Phosphorothioate DNAzyme for the Detection of Thallium
Huang, Po-Jung Jimmy; Vazin, Mahsa; Liu, Juewen (American Chemical Society, 2015-10-20)Thallium (Tl) is a highly toxic heavy metal situated between mercury and lead in the periodic table. While its neighbors have been thoroughly studied for DNA-based sensing, little is known about thallium detection. In this ... -
Distinction of Individual Lanthanide Ions with a DNAzyme Beacon Array
Huang, Po-Jung Jimmy; Vazin, Mahsa; Lin, Jennifer J.; Pautler, Rachel; Liu, Juewen (American Chemical Society, 2016-06-24)Developing chemical probes to distinguish each lanthanide ion is a long-standing challenge. Aside from its analytical applications, solving this problem will also enhance our knowledge in metal ligand design. Using in vitro ... -
In Vitro Selection of a DNAzyme Cooperatively Binding Two Lanthanide Ions for RNA Cleavage
Huang, Po Jung Jimmy; Vazin, Mahsa; Liu, Juewen (American Chemical Society, 2016-05-03)Trivalent lanthanide ions (Ln(3+)) were recently employed to select RNA-cleaving DNAzymes, and three new DNAzymes have been reported so far. In this work, dysprosium (Dy3+) was used with a library containing 50 random ... -
In Vitro Selection of a New Lanthanide-Dependent DNAzyme for Ratiometric Sensing Lanthanides
Huang, Po-Jung Jimmy; Vazin, Mahsa; Liu, Juewen (American Chemical Society, 2014-10-07)Developing biosensors for lanthanides is an important but challenging analytical task. To address this problem, in vitro selection of RNA-cleaving DNAzymes was carried out using a library containing a region of 35 random ... -
In Vitro Selection of Chromium-Dependent DNAzymes for Sensing Chromium(III) and Chromium(VI)
Zhou, Wenhu; Vazin, Mahsa; Yu, Tianmeng; Ding, Jinsong; Liu, Juewen (Wiley, 2016-07-04)Chromium is a very important analyte for environmental monitoring, and developing biosensors for chromium is a long-standing analytical challenge. In this work, in vitro selection of RNA-cleaving DNAzymes was carried out ...