Browsing Waterloo Research by Author "Scott, Bradley"
Now showing items 1-2 of 2
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An Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wall
Taylor, Robert; Scott, Bradley; Taylor, Scott D.; Palmer, Michael (American Chemical Society, 2017-03-28)The lipopeptide antibiotic daptomycin is active against Gram-positive pathogens. It permeabilizes bacterial cell membranes, which involves the formation of membrane-associated oligomers. We here studied a dimer of daptomycin ... -
Two successive calcium-dependent transitions mediate membrane binding and oligomerization of daptomycin and the related antibiotic A54145
Taylor, Robert; Butt, Khalida; Scott, Bradley; Zhang, TianHua; Muraih, Jawad K.; Mintzer, Evan; Taylor, Scott D.; Palmer, Michael (Elsevier, 2016-09)Daptomycin and A54145 are homologous lipopeptide antibiotics that permeabilize the cell membranes of Gram-positive bacteria. Membrane permeabilization depends on the presence of both phosphatidylglycerol (PG) and calcium, ...