Browsing Physics and Astronomy by Author "Wang, Chunrong"
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Prehydrated Electron and Its Role in Ionizing Radiation Induced DNA Damage and Molecular Mechanisms of Action of Halogenated Sensitizers for Radiotherapy of Cancer
Wang, Chunrong (University of Waterloo, 2012-10-05)Despite advances in technology and understanding of biological systems in the past two decades, modern drug discovery is still a lengthy, expensive, difficult and inefficient process with low rate of new therapeutic ... -
REAL-TIME OBSERVATION OF MOLECULAR REACTION MECHANISM OF HALOPYRIMIDINES AS RADIO-/PHOTOSENSITIZING DRUGS USING TIME-RESOLVED FEMTOSECOND LASER SPECTROSCOPY
Wang, Chunrong (University of Waterloo, 2007-05-22)Replacement of thymidine in DNA by halopyrimidines, such as bromodeoxyuridine (BrdU) and iododeoxyuridine (IdU), has long been known to enhance DNA damage and cell death induced by ionizing/UV radiation, but the mechanism ...