Pharmacy: Recent submissions
Now showing items 21-40 of 137
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Design of a DNA-Encoded Human Papilloma Virus-Like Particle Displaying a Vascular Endothelial Growth Factor Antagonistic Peptide for Characterization in Mammalian Cells
(University of Waterloo, 2022-12-21)Cancer immunotherapy has evolved as an effective platform for the treatment of a variety of cancer types by enhancing and/or modulating the functionality of the immune system to target cancer cells and consequently mitigate ... -
Understanding the dynamics and molecular interactions of the human cannabinoid receptor 1
(University of Waterloo, 2022-08-23)Cannabinoid receptor 1 (CB1), one of the most populated G-protein coupled receptors (GPCR) present within the brain, is involved in various physiological and homeostatic processes. These pathways include metabolism and ... -
Model-Based Estimation of the Prevalence of Chronic Hepatitis B in Canada and Cost-Effectiveness Analysis of Implementing a Universal Birth Hepatitis B Vaccination Program in Ontario, Canada
(University of Waterloo, 2022-07-26)BACKGROUND Hepatitis B is a potentially life-threatening acute or chronic disease that is caused by hepatitis B virus (HBV). The development of chronic disease is age-dependent, with the highest risk in the infant population. ... -
A bacteria-responsive drug release platform for the local treatment of bacterial vaginosis
(University of Waterloo, 2022-07-25)Bacterial vaginosis (BV) is a common vaginal anaerobic dysbiosis affecting millions of women, with a high recurrence rate probably due to the stubborn existence of biofilms and Gardnerella vaginalis (G. vaginalis) as the ... -
Pharmacy5in5: Evaluating a computer-based education platform to improve pharmacists’ knowledge and behaviour
(University of Waterloo, 2022-05-30)Background The pharmacist’s role continues to evolve and expand from the traditional role of dispensing to a more patient-centered model of care. However, many pharmacists still fall short in terms of their provision of ... -
Endocannabinoids as Amyloid-Beta (Aβ) Aggregation Inhibitors
(University of Waterloo, 2022-05-13)The endocannabinoid system, including endogenous cannabinoids and their corresponding receptors, has received extensive attention in the last few years for their neuroprotective effect in the central nervous system. The ... -
Integration of Smart Multidose Blister Packaging for Medication Management
(University of Waterloo, 2022-04-26)Medication non-adherence can lead to non-optimal management of chronic diseases and poor health outcomes. Numerous innovative dispensing products offering real-time medication intake monitoring are being developed and ... -
Construction and characterization of a hybrid bacteriophage gene delivery platform
(University of Waterloo, 2022-04-26)Bacteriophages, viruses that specifically infect bacteria, may be considered as structurally simplistic protein-based vehicles for ferrying nucleic acid cargo. Since phages cannot infect nor replicate within human cells, ... -
Impact of sex and pathophysiology on optimal drug choice in hypertensive rats: Quantitative insights for precision medicine
(Elsevier, 2021-04)Less than half of all hypertensive patients receiving treatment are successful in normalizing their blood pressure. Despite the complexity and heterogeneity of hypertension, the current antihypertensive guidelines are not ... -
Sex differences in solute and water handling in the human kidney: Modeling and functional implications
(Elsevier, 2021-06)The kidneys maintain homeostasis by controlling the amount of water and electrolytes in the blood. That function is accomplished by the nephrons, which transform glomerular filtrate into urine by a transport process mediated ... -
Aging affects circadian clock and metabolism and modulates timing of medication
(Elsevier, 2021-04)Aging is associated with impairments in the circadian rhythms, and with energy deregulation that affects multiple metabolic pathways. The goal of this study is to unravel the complex interactions among aging, metabolism, ... -
Appendix to "Characteristics, predictors, and reasons for regulatory body disciplinary action in health care: A scoping review"
(Journal of Medical Regulation, 2022-01)In this appendix to the manuscript "Characteristics, predictors, and reasons for regulatory body disciplinary action in health care: A scoping review”, the studies included in the scoping review are summarized. -
Development of Novel Molecules as Modulators of Amyloid-β Aggregation
(University of Waterloo, 2021-09-08)Our brain is remarkably special and unique. It has billions of neurons that govern actions and reactions, and enables us to have thoughts, memories, and personality traits – outmost precious assets – that define who we are ... -
Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Children
(University of Waterloo, 2021-06-25)The following thesis chapters chronicle evolving efforts throughout 2016 – 2021 to support research toward improving the pediatric clinical pharmacology of monoclonal antibodies (mAbs). Translating the benefits of successful ... -
Development and characterization of stimuli-responsive drug delivery systems to prevent HIV infection and the treatment of chronic wounds
(University of Waterloo, 2021-06-10)Patient compliance is very important and highly depends on the drug dosage form which correlates with the success of therapy. Drug delivery systems can be adapted to different pharmaceutical ingredients and to different ... -
Comparative risk of cardiac arrhythmias associated with acetylcholinesterase inhibitor use
(University of Waterloo, 2021-05-19)Background: Acquired long-QT syndrome (ALQTS) and its associated condition, torsades de pointes (TdP – a malignant cardiac arrhythmia), are associated with the use of certain medications. Case reports and pharmacodynamic ... -
Potential of surface modified exosomes for extended intravitreal drug delivery
(University of Waterloo, 2021-04-30)Diabetic retinopathy is a serious condition affecting retinal cells that can lead to blindness. Intravitreal injection is the only feasible method of drug delivery to the retina. However, intravitreal injections are only ... -
Determination of the relationship between vancomycin trough concentrations and the AUC/MIC Dosing
(University of Waterloo, 2020-07-15)Rationale: The recently revised guidelines for the therapeutic monitoring of vancomycin recommend targeting an AUC/MIC of 400-600 for serious methicillin-resistant Staphylococcus aureus (MRSA) infections. The feasibility ... -
Risk and Benefit of Warfarin for Primary Prevention in Atrial Fibrillation Patients on Hemodialysis: A Retrospective Pilot Study
(University of Waterloo, 2020-07-17)Background Despite increased awareness and advocacy regarding the opioid epidemic, data from Health Quality Ontario (HQO) shows steady prescribing of opioids with concerning trends toward prescribing more potent opioids. ... -
Development of a Novel, Microemulsion System for the Simultaneous Delivery of Hydrophilic and Hydrophobic Active Pharmaceutical Ingredients (APIs)
(University of Waterloo, 2020-09-28)Concurrent chronic disease and ensuing multi-morbidity are a debilitating reality for millions of Canadians. This adversity is compounded by increased pill burden and decreased patient adherence. Microemulsions (MEs) serve ...