Browsing Pharmacy by Issue Date
Now showing items 21-40 of 137
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Prevalence of Potentially Inappropriate Medications Use Among Recently Admitted Geriatric Patients in Rural Hospitals
(University of Waterloo, 2014-12-11)Potentially inappropriate medications (PIMs) are prescribed most often to elderly patients and can cause serious adverse effects. Older adults tend to use multiple medications, and age-related physiological changes can ... -
Synthesis of Multiply Deuterated Cephalosporins
(University of Waterloo, 2014-12-12)Antibiotics are one of the greatest accomplishments in the field of science. They have been extensively used since the time of their discovery. Amongst all the antibiotics, the -lactam class of antibiotics have been the ... -
Design, synthesis and biological evaluation of novel tricyclics as dual cholinesterase (ChE) and amyloid aggregation inhibitors with antioxidant properties
(University of Waterloo, 2014-12-12)Alzheimer’s disease (AD) is a complex neurodegenerative disease affecting the cholinergic region of the brain. Its prevalence is steadily increasing and it is becoming one of the highest costing diseases to modern society. ... -
Evaluating the anti-leukemia activity of avocatin B
(University of Waterloo, 2015-01-15)Acute myeloid leukemia (AML) is an aggressive malignant disease characterized by poor patient outcome and suboptimal front-line chemotherapy. To identify novel anti-AML compounds, a high-throughput screen of a natural ... -
Characterization of counterion effects of gemini surfactants and in vitro studies of transfection efficiency for gene therapy in epithelial ovarian cancer.
(University of Waterloo, 2015-01-23)Gene therapy has emerged as a promising strategy for the treatment or prevention of many acquired or genetic diseases that are considered incurable at the present time. Although viral and non-viral vector approaches are ... -
Using a collaborative research approach to develop an interdisciplinary research agenda for the study of mobile health interventions for older adults.
(JMIR Mhealth Uhealth., 2015-02-10)Background: Seniors with chronic diseases are often called on to self-manage their conditions. Mobile health (mHealth) tools may be a useful strategy to help seniors access health information at the point of decision-making, ... -
Evaluating the Usability of a Medication Organizing Tool on Home Medication Management - A Proof-of-Concept Experiment
(University of Waterloo, 2015-02-20)Background: Chronic disease and medication self-management is a life-long process in which patient self-efficacy plays an important role in determining success. Efforts to improve self-management have traditionally focused ... -
Consequences of a lack of adult intravenous data on the prediction accuracy of pediatric physiologically based pharmacokinetic (PBPK) modeling
(University of Waterloo, 2015-05-22)Lack of pediatric clinical data has led to a large gap in knowledge concerning drug efficacy, safety and dosing guidelines within the pediatric population. Many pediatric off-label doses are based largely on adult studies ... -
Evaluating Nutraceuticals for Selective Toxicity Toward Leukemia Stem Cells
(University of Waterloo, 2015-05-22)Targeting leukemia stem cells (LSCs) is critical to improving the poor outcome of acute myeloid leukemia (AML) patients. Nutraceuticals (i.e., food derived bioactive compounds) provide a wealthy resource for novel ... -
Metabolism, transport, and physiologically based pharmacokinetic modelling of novel tacrine derivatives
(University of Waterloo, 2015-08-26)Alzheimer’s disease (AD) is the most prevalent form of dementia affecting the elderly population, and its burden is rapidly growing both in Canada and worldwide. As a result, there is a substantial need for more effective ... -
Isolation and Characterization of Host Mutations that Suppress the Bacteriophage Lambda (λ) Rex Phenotype
(University of Waterloo, 2015-09-01)The Bacteriophage lambda (λ) T4rII exclusion (Rex) phenotype is defined as the inability of T4rII mutant bacteriophage to form plaques on a lawn of E. coli lysogenized by bacteriophage λ. More than six decades have passed ... -
Assessing Medication Adherence in Older Adults with Memory Concerns in a Primary Care-Based Memory Clinic
(University of Waterloo, 2015-10-02)There is an increasing prevalence of cognitive impairment in the rapidly ageing population. Cognitive impairment has been shown to be a unique barrier to medication adherence in older adults coupled with an increased number ... -
Mobile Technology and Health Literacy Regarding Medication Information
(University of Waterloo, 2015-10-05)Low health literacy is one of the main barriers to medication adherence. People with low literacy often have difficulty understanding health information and making appropriate health decisions. Currently, medication ... -
Investigating the neuroprotective potential of short-term 5-HT7 receptor activation against neuronal excitotoxicity
(University of Waterloo, 2015-10-05)The pathophysiology of cerebral ischemia or acute ischemic stroke involves what is called neuronal "excitotoxicity", where an initial failure in intracellular energy metabolism causes excessive pre-synaptic glutamate release ... -
Langmuir-Blodgett Monolayer Studies of Mixed Gemini Surfactant-Phospholipid Monolayers system for Gene Therapy Applications.
(University of Waterloo, 2015-10-23)Gene delivery relies upon the encapsulation of a gene of interest, which is then ideally delivered to target cells. For gene therapy applications, viral vectors are the most efficient vectors currently being studied, ... -
Alterations in Colorectal Cancer Cell-extracellular Matrix Interactions Upon Acquisition of Chemotherapy Resistance.
(University of Waterloo, 2015-12-16)Adjuvant chemotherapy is an essential component in the treatment of advanced colorectal cancer (CRC). Unfortunately, many patients experience recurrence with aggressive, chemotherapy-resistant disease for which the prognosis ... -
Supporting student development through a cooperative education coaching program
(International Journal of Work-Integrated Learning, 2016)Uptake of new scopes of practice by pharmacists has been slow and inconsistent, which the literature suggests may be related to disconnects between pharmacists' established professional identities and the identities needed ... -
Acceptance of Commercially Available Wearable Activity Trackers Among Adults Aged Over 50 and With Chronic Illness: A Mixed-Methods Evaluation
(JMIR Mhealth Uhealth., 2016-01-27)Background: Physical inactivity and sedentary behavior increase the risk of chronic illness and death. The newest generation of “wearable” activity trackers offers potential as a multifaceted intervention to help people ... -
Behavior Change Techniques Present in Wearable Activity Trackers: A Critical Analysis
(JMIR mHealth and uHealth, 2016-04-27)Background: Wearable activity trackers are promising as interventions that offer guidance and support for increasing physical activity and health-focused tracking. Most adults do not meet their recommended daily activity ... -
In-Silico Methods for De-Risking the Clinical Development of Subcutaneously Administered Therapeutic Macromolecules
(University of Waterloo, 2016-07-27)Prediction of human pharmacokinetics (PK) following subcutaneous (SC) administration to animals is challenged by potential interspecies differences in skin anatomy and physiology. With respect to biologic or macromolecule ...