Browsing Pharmacy by Title
Now showing items 85-104 of 105
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Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Children
(University of Waterloo, 2021-06-25)The following thesis chapters chronicle evolving efforts throughout 2016 – 2021 to support research toward improving the pediatric clinical pharmacology of monoclonal antibodies (mAbs). Translating the benefits of successful ... -
Physiologically-based pharmacokinetic model for ciprofloxacin in children with complicated urinary tract infection
(Elsevier, 2019-02-01)In a recent multicenter population pharmacokinetic study of ciprofloxacin administered to children suffering from complicated urinary tract infection (cUTI), the apparent volume of distribution (V) and total plasma clearance ... -
A Picture is Worth a Thousand Words: A Randomized Controlled Trial to Assess the Impact of a Computerized Pictorial Medication Calendar Medication Taking Behaviour
(University of Waterloo, 2017-08-11)OBJECTIVES The primary was to determine if a pictorial medication calendar would improve patient adherence to supportive medication regimens for adult patients receiving chemotherapy treatment. The secondary objectives ... -
Pluronic-Based Nanoparticles for Gene Therapy Applications
(University of Waterloo, 2014-01-24)Non-viral delivery vectors have potential advantages over the viral systems that currently are used extensively for delivering therapeutic genes of interest. However, non-viral gene therapy has low efficiencies in vivo, ... -
Potential of surface modified exosomes for extended intravitreal drug delivery
(University of Waterloo, 2021-04-30)Diabetic retinopathy is a serious condition affecting retinal cells that can lead to blindness. Intravitreal injection is the only feasible method of drug delivery to the retina. However, intravitreal injections are only ... -
Prevalence of Potentially Inappropriate Medications Use Among Recently Admitted Geriatric Patients in Rural Hospitals
(University of Waterloo, 2014-12-11)Potentially inappropriate medications (PIMs) are prescribed most often to elderly patients and can cause serious adverse effects. Older adults tend to use multiple medications, and age-related physiological changes can ... -
Procedure-specific Risks of Thrombosis and Bleeding in Urological Non-cancer Surgery: Systematic Review and Meta-analysis
(Elsevier, 2018-02-01)Context Pharmacological thromboprophylaxis involves a trade-off between a reduction in venous thromboembolism (VTE) and increased bleeding. No guidance specific for procedure and patient factors exists in urology. Objective ... -
A Quality Assurance Evaluation of Hydromorphone Adverse Events Post-Implementation of a Safety Initiative
(University of Waterloo, 2019-08)Purpose: Hydromorphone is a potent opioid that may lead to respiratory and central nervous system depression prompting naloxone use. The primary objective of this study was to evaluate whether a safety initiative implemented ... -
Risk and Benefit of Warfarin for Primary Prevention in Atrial Fibrillation Patients on Hemodialysis: A Retrospective Pilot Study
(University of Waterloo, 2019-07)Rationale: Although warfarin is an established anticoagulation therapy for prevention of ischemic strokes in patients with atrial fibrillation, studies reporting INR values with correlation to warfarin efficacy and safety ... -
Risk and Benefit of Warfarin for Primary Prevention in Atrial Fibrillation Patients on Hemodialysis: A Retrospective Pilot Study
(University of Waterloo, 2020-07-17)Background Despite increased awareness and advocacy regarding the opioid epidemic, data from Health Quality Ontario (HQO) shows steady prescribing of opioids with concerning trends toward prescribing more potent opioids. ... -
The risk of fragility fractures in new users of dipeptidyl peptidase-4 inhibitors compared to sulfonylureas and other anti-diabetic drugs: A cohort study
(Elsevier, 2018-02-01)Aims Mixed evidence exists for the effect of incretin-based therapies on osteoporosis in type-2 diabetes. Therefore, we conducted a cohort study to determine the association between dipeptidyl peptidase-4 (DPP-4) inhibitors ... -
The risk of fragility fractures in new users of dipeptidyl peptidase-4 inhibitors compared to sulfonylureas and other anti-diabetic drugs: A cohort study
(Elsevier, 2018-02-01)Aims Mixed evidence exists for the effect of incretin-based therapies on osteoporosis in type-2 diabetes. Therefore, we conducted a cohort study to determine the association between dipeptidyl peptidase-4 (DPP-4) inhibitors ... -
Role of Prolyl 4-Hydroxylase in Pancreatic ß-cell Insulin Secretion
(University of Waterloo, 2017-08-30)Type 2 diabetes mellitus (T2D) is characterized by chronic hyperglycemia and peripheral insulin resistance. In response to elevated blood glucose levels, pancreatic β-cells release insulin which occurs in a biphasic ... -
A Scoping Review of Frailty and Acute Care in Middle-Aged and Older Individuals with Recommendations for Future Research
(Canadian Geriatrics Society, 2017-03-31)There is general agreement that frailty is a state of heightened vulnerability to stressors arising from impairments in multiple systems leading to declines in homeostatic reserve and resiliency, but unresolved issues ... -
Shades of gray in vaccine decision making: Understanding, exploring, and addressing the challenges of influenza vaccine hesitancy in Ontario community pharmacies
(University of Waterloo, 2019-12-19)Background: Two-thirds of Canadian adults currently do not receive the annual influenza vaccine. Vaccine hesitancy (VH), the voluntary delay or refusal of vaccination services despite availability is a significant contributor ... -
Supporting student development through a cooperative education coaching program
(International Journal of Work-Integrated Learning, 2016)Uptake of new scopes of practice by pharmacists has been slow and inconsistent, which the literature suggests may be related to disconnects between pharmacists' established professional identities and the identities needed ... -
Synthesis and Characterisation of Chiral Nanomaterials and their Influence on Stem Cell Differentiation
(University of Waterloo, 2017-08-11)Tissue engineering is a field related to regenerative medicine which aims at replacing or regenerating a patient’s tissue, usually using a combination of cells and a bioactive material which is designed to influence cell ... -
Synthesis of Multiply Deuterated Cephalosporins
(University of Waterloo, 2014-12-12)Antibiotics are one of the greatest accomplishments in the field of science. They have been extensively used since the time of their discovery. Amongst all the antibiotics, the -lactam class of antibiotics have been the ... -
Transactivation of platelet-derived growth factor receptor type β: Mechanisms and potential relevance in neurobiology
(University of Waterloo, 2013-12-23)In the absence of ligand, certain growth factor receptors can be activated via G protein-coupled receptor (GPCR) activation in a process termed transactivation. Serotonin (5-HT) receptors can transactivate the receptor ... -
Understanding the Relationship Between Pharmacists’ Implicit and Explicit Bias and Perceptions of Pharmacist Services Among Arab and Black Individuals
(University of Waterloo, 2019-11-27)Background. Recent studies suggest that Health Care Professionals’ (HCPs) unconscious bias about race contributes to health care disparities. The objective of this research was to estimate unconscious racial bias among ...