Browsing Pharmacy by Title
Now showing items 75-94 of 132
-
In-Silico Methods for De-Risking the Clinical Development of Subcutaneously Administered Therapeutic Macromolecules
(University of Waterloo, 2016-07-27)Prediction of human pharmacokinetics (PK) following subcutaneous (SC) administration to animals is challenged by potential interspecies differences in skin anatomy and physiology. With respect to biologic or macromolecule ... -
In-solution and physical state properties of polymer and lipid excipients and their effects on the supersaturation evolution of poorly water-soluble drugs
(University of Waterloo, 2023-04-14)Solubility has become an increasing issue for the pharmaceutical industry, as the advances in combinatorial chemistry and high throughput screening methods have resulted in an increase in the molecular weight and lipophilicity ... -
Incorporating sex, gender and vulnerable populations in a large multisite health research programme: The Ontario Pharmacy Evidence Network as a case study
(BioMed Central, 2017-03-20)Background: Funders now frequently require that sex and gender be considered in research programmes, but provide little guidance about how this can be accomplished, especially in large research programmes. The purpose of ... -
Integration of Smart Multidose Blister Packaging for Medication Management
(University of Waterloo, 2022-04-26)Medication non-adherence can lead to non-optimal management of chronic diseases and poor health outcomes. Numerous innovative dispensing products offering real-time medication intake monitoring are being developed and ... -
The Interplay Between the Neuronal Plasma Membrane and Cell Signaling in Alzheimer’s Disease
(University of Waterloo, 2023-03-10)The lack of understanding in the molecular and cellular mechanisms of Alzheimer’s disease (AD) has hindered efforts towards finding treatments that effectively modify disease trajectory. Therapeutic development for AD has ... -
Investigating the Interactions of Fatty Acids, Amyloid Beta & SARS-CoV-2 Spike Protein Fragment
(University of Waterloo, 2023-05-16)There is no cure for Alzheimer’s disease (AD), and the negative implications of having AD were further exacerbated in recent years, as patients with dementia are at the highest risk for mortality upon contracting COVID-19. ... -
Investigating the neuroprotective potential of short-term 5-HT7 receptor activation against neuronal excitotoxicity
(University of Waterloo, 2015-10-05)The pathophysiology of cerebral ischemia or acute ischemic stroke involves what is called neuronal "excitotoxicity", where an initial failure in intracellular energy metabolism causes excessive pre-synaptic glutamate release ... -
Isolation and Characterization of Host Mutations that Suppress the Bacteriophage Lambda (λ) Rex Phenotype
(University of Waterloo, 2015-09-01)The Bacteriophage lambda (λ) T4rII exclusion (Rex) phenotype is defined as the inability of T4rII mutant bacteriophage to form plaques on a lawn of E. coli lysogenized by bacteriophage λ. More than six decades have passed ... -
Lack of neuroprotective effects by platelet-derived growth factor against beta-amyloid induced toxicity uncovers a novel hypothesis of Alzheimer's disease pathology
(University of Waterloo, 2012-05-18)Aβ oligomer-induced neurotoxicity has become an important area of therapeutic development in treating Alzheimer’s disease. Platelet-derived growth factor (PDGF) has been shown to be able to protect neurons against several ... -
Langmuir-Blodgett Monolayer Studies of Mixed Gemini Surfactant-Phospholipid Monolayers system for Gene Therapy Applications.
(University of Waterloo, 2015-10-23)Gene delivery relies upon the encapsulation of a gene of interest, which is then ideally delivered to target cells. For gene therapy applications, viral vectors are the most efficient vectors currently being studied, ... -
Machine learning modelling in predicting and optimizing PLGA nanoparticle encapsulation efficiency and therapeutic efficacy
(University of Waterloo, 2023-09-20)Nanoparticles (NP) have become a promising drug delivery system in the past few decades in pharmaceutics for its diversity in encapsulating different types of drugs, including proteins/peptides, nucleic acids and small ... -
Metabolism, transport, and physiologically based pharmacokinetic modelling of novel tacrine derivatives
(University of Waterloo, 2015-08-26)Alzheimer’s disease (AD) is the most prevalent form of dementia affecting the elderly population, and its burden is rapidly growing both in Canada and worldwide. As a result, there is a substantial need for more effective ... -
Mixed Micelle Characterization of Pluronic and Gemini Surfactant – Based Gene Therapy Carriers and a Connection to Transfection Efficiency
(University of Waterloo, 2020-09-16)Non-viral gene therapy formulation development often relies on a rational design approach, where vector components are selected based on individual characteristics known to favour transfection efficiency. However, these ... -
Mobile Technology and Health Literacy Regarding Medication Information
(University of Waterloo, 2015-10-05)Low health literacy is one of the main barriers to medication adherence. People with low literacy often have difficulty understanding health information and making appropriate health decisions. Currently, medication ... -
Model-Based Estimation of the Prevalence of Chronic Hepatitis B in Canada and Cost-Effectiveness Analysis of Implementing a Universal Birth Hepatitis B Vaccination Program in Ontario, Canada
(University of Waterloo, 2022-07-26)BACKGROUND Hepatitis B is a potentially life-threatening acute or chronic disease that is caused by hepatitis B virus (HBV). The development of chronic disease is age-dependent, with the highest risk in the infant population. ... -
Modeling of Body Weight Metrics for Effective and Cost-Efficient Conventional Factor VIII Dosing in Hemophilia A Prophylaxis
(MDPI, 2017-12-01)The total body weight-based dosing strategy currently used in the prophylactic treatment of hemophilia A may not be appropriate for all populations. The assumptions that guide weight-based dosing are not valid in overweight ... -
Multiscale models of kidney function and diseases
(Elsevier, 2019-09)The kidney is a complex system whose function is the result of synergistic operations among a number of biological processes. The spatial and functional scales of those processes span a wide range. To interrogate kidney ... -
“My pharmacist”: Creating and maintaining relationship between physicians and pharmacists in primary care settings
(Elsevier, 2020-01)Background Pharmacists and physicians are being increasingly encouraged to adopt a collaborative approach to patient care, and delivery of health services. Strong collaboration between pharmacists and physicians is known ... -
Network centrality analysis of eye-gaze data in autism spectrum disorder
(Elsevier, 2019-08)Individuals suffering from autism spectrum disorder (ASD) exhibit impaired social communication, the manifestations of which include abnormal eye contact and gaze. In this study, we first seek to characterize the spatial ... -
Non-viral gemini surfactant-phospholipid nanoparticles for topical gene delivery to the retina
(University of Waterloo, 2013-01-29)Glaucoma is a group of optic nerve degenerative diseases, which leads to gradual and permanent vision loss. Recent developments in the field of gene therapy have proposed increasingly promising treatments for glaucoma, in ...