Browsing Pharmacy by Title
Now showing items 43-62 of 137
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Development of a correlation based and a decision tree based prediction algorithm for tissue to plasma partition coefficients
(University of Waterloo, 2013-04-29)Physiologically based pharmacokinetic (PBPK) modeling is a tool used in drug discovery and human health risk assessment. PBPK models are mathematical representations of the anatomy, physiology and biochemistry of an organism. ... -
Development of a Framework for Identifying Critical Input Parameters for Effective Pediatric PBPK/PBTK Modelling
(University of Waterloo, 2023-01-20)Within a physiologically based pharmacokinetic (PBPK) model framework, virtual children are built based on known trajectories of anatomy and physiology across age and a compounds transfer within the body is defined by ... -
Development of a Novel, Microemulsion System for the Simultaneous Delivery of Hydrophilic and Hydrophobic Active Pharmaceutical Ingredients (APIs)
(University of Waterloo, 2020-09-28)Concurrent chronic disease and ensuing multi-morbidity are a debilitating reality for millions of Canadians. This adversity is compounded by increased pill burden and decreased patient adherence. Microemulsions (MEs) serve ... -
Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo): Study Protocol
(JMIR Publications, 2016-12-15)Background: Individual pharmacokinetic assessment is a critical component of tailored prophylaxis for hemophilia patients. Population pharmacokinetics allows using individual sparse data, thus simplifying individual ... -
Development of in vitro 3D model systems for screening non-viral neurotrophic factor gene therapies for the retina
(University of Waterloo, 2018-08-21)Glaucoma is a neurodegenerative disease that can lead to a complete loss of vision due to retinal ganglion cell (RGC) death. Therapies that have the capacity to protect and rescue stressed RGCs remain a critical unmet need ... -
Development of Modular Polymeric NPs for Drug Delivery Using Amine-Reactive Chemistry
(University of Waterloo, 2024-01-26)Cancer remains one of the leading causes of death worldwide and very often requires chemotherapy treatment. Despite advances in chemotherapy treatments, some cancers remain difficult to treat due to tumour type, location, ... -
Development of Novel Molecules as Modulators of Amyloid-β Aggregation
(University of Waterloo, 2021-09-08)Our brain is remarkably special and unique. It has billions of neurons that govern actions and reactions, and enables us to have thoughts, memories, and personality traits – outmost precious assets – that define who we are ... -
Development of Peptide-Modified Gemini Nanoplexes for Gene Delivery to the Retina
(University of Waterloo, 2020-04-22)Glaucoma is a retinal neurodegenerative disease where the retinal ganglion cells (RGCs) suffer from damage and die over time due to multiple factors, including a persistently elevated intraocular pressure (IOP). Glaucoma ... -
Droplet Microfluidic System with On-Demand Trapping and Releasing of Droplet for Drug Screening Applications
(American Chemical Society (ACS), 2017-01-03)96-Well plate has been the traditional method used for screening drug compounds libraries for potential bioactivity. Although this method has been proven successful in testing doseÐresponse analysis, the microliter consumption ... -
Dynamic mechanical behaviour of nanoparticle loaded biodegradable PVA films for vaginal drug delivery
(Sage Publishing, 2018-03-01)In this study, we investigated the viscoelastic and mechanical behaviour of polyvinyl alcohol films formulated along with carrageenan, plasticizing agents (polyethylene glycol and glycerol), and when loaded with nanoparticles ... -
Effect of a Mobile Phone Intervention on Quitting Smoking in a Young Adult Population of Smokers: Randomized Controlled Trial
(JMIR, 2018-10-23)Background: Digital mobile technology presents a promising medium for reaching young adults with smoking cessation interventions because they are the heaviest users of this technology. Objective: The aim of this study ... -
The Effect of a Source Change for an Active Pharmaceutical Ingredient (API) or Excipient on the Finished Drug Product
(University of Waterloo, 2016-08-10)The global cost of health care is increasing year after year, and one of the ways governments and health care providers are looking to reduce cost is by reducing the cost of drug products. The generic industry is under ... -
Effect of Gemini Surfactants on Amyloid Beta Aggregation
(University of Waterloo, 2013-09-27)Alzheimer’s disease (AD) is a progressive dementia affecting cognition, behavior, and functional status and there is no cure which exists for it. In AD, Amyloid Beta (Aβ) peptides form aggregates that are neurotoxic in the ... -
The Effects of Autophagic Deficiencies on the Leukemia Mitochondrial Phenotype and Implications in Strategic Drug Targeting
(University of Waterloo, 2016-12-13)Acute myeloid leukemia (AML) is a cancer that develops when hematopoietic stem cells in the bone marrow transform into malignant cells and subsequently grow and replicate aberrantly. Autophagy, a pathway by which cellular ... -
Endocannabinoids as Amyloid-Beta (Aβ) Aggregation Inhibitors
(University of Waterloo, 2022-05-13)The endocannabinoid system, including endogenous cannabinoids and their corresponding receptors, has received extensive attention in the last few years for their neuroprotective effect in the central nervous system. The ... -
Enhancing the Ministring DNA (msDNA) Purification Using PI-Sce1 Homing Endonuclease/CRISPR-Cas3 Recombinant System
(University of Waterloo, 2024-02-05)In the generation of msDNA the recombinant E. coli cells are transformed by a msDNA generating precursor plasmid, whereupon expression of the Tel protelomerase enzyme, acting on the pal target sequence present in the ... -
Ethynyl-1,1’-Biphenyl Derivatives as Amyloid Beta Aggregation Inhibitors
(University of Waterloo, 2019-12-19)Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder, with characteristic symptoms including memory loss and cognitive decline. AD is characterized by the formation of dense amyloid β (Aβ) plaques and ... -
Evaluating Nutraceuticals for Selective Toxicity Toward Leukemia Stem Cells
(University of Waterloo, 2015-05-22)Targeting leukemia stem cells (LSCs) is critical to improving the poor outcome of acute myeloid leukemia (AML) patients. Nutraceuticals (i.e., food derived bioactive compounds) provide a wealthy resource for novel ... -
Evaluating the anti-leukemia activity of avocatin B
(University of Waterloo, 2015-01-15)Acute myeloid leukemia (AML) is an aggressive malignant disease characterized by poor patient outcome and suboptimal front-line chemotherapy. To identify novel anti-AML compounds, a high-throughput screen of a natural ... -
Evaluating the Usability of a Medication Organizing Tool on Home Medication Management - A Proof-of-Concept Experiment
(University of Waterloo, 2015-02-20)Background: Chronic disease and medication self-management is a life-long process in which patient self-efficacy plays an important role in determining success. Efforts to improve self-management have traditionally focused ...