Browsing Pharmacy by Title
Now showing items 35-54 of 131
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Design, Synthesis and Biological Evaluation of 2,4-Disubstituted Pyrimidine Derivatives: Multifunctional Candidates as Potential Treatment Options for Alzheimer’s Disease
(University of Waterloo, 2011-08-30)Alzheimer’s disease (AD) is a highly complex and rapidly progressive neurodegenerative disorder characterized by the systemic collapse of cognitive function and formation of dense amyloid-β (Aβ) plaques and neurofibrillary ... -
Design, Synthesis and Biological Evaluation of Novel Adamantane Derivatives as Potential Treatments for Alzheimer’s Disease
(University of Waterloo, 2017-02-14)Alzheimer’s disease (AD) is a complex, multifactorial, and rapidly neurodegenerative disorder characterized by cognitive impairment and progressive dementia. Its pathology was first characterized by Alois Alzheimer as “a ... -
Design, synthesis and biological evaluation of novel tricyclics as dual cholinesterase (ChE) and amyloid aggregation inhibitors with antioxidant properties
(University of Waterloo, 2014-12-12)Alzheimer’s disease (AD) is a complex neurodegenerative disease affecting the cholinergic region of the brain. Its prevalence is steadily increasing and it is becoming one of the highest costing diseases to modern society. ... -
Design, Synthesis, and Evaluation of Tacrine-Based Derivatives: Potential Agents to Treat Alzheimer’s Disease
(University of Waterloo, 2013-08-01)With the incidence of Alzheimer’s disease (AD) growing worldwide and in Canada along with the growing economic and social burdens, the need for more effective therapies becomes of great importance. Since the discovery of ... -
Determination of the relationship between vancomycin trough concentrations and the AUC/MIC Dosing
(University of Waterloo, 2020-07-15)Rationale: The recently revised guidelines for the therapeutic monitoring of vancomycin recommend targeting an AUC/MIC of 400-600 for serious methicillin-resistant Staphylococcus aureus (MRSA) infections. The feasibility ... -
Development and characterization of stimuli-responsive drug delivery systems to prevent HIV infection and the treatment of chronic wounds
(University of Waterloo, 2021-06-10)Patient compliance is very important and highly depends on the drug dosage form which correlates with the success of therapy. Drug delivery systems can be adapted to different pharmaceutical ingredients and to different ... -
Development and Testing of a Framework for the Assessment of Health-Related Risks Among Travellers by Pharmacists in Ontario
(University of Waterloo, 2019-12-18)As pharmacists move away from traditional dispensary roles and towards more clinical services, a therapeutic realm that pharmacists are exploring is travel medicine. However, travel medicine can be challenging to beginners ... -
Development of a correlation based and a decision tree based prediction algorithm for tissue to plasma partition coefficients
(University of Waterloo, 2013-04-29)Physiologically based pharmacokinetic (PBPK) modeling is a tool used in drug discovery and human health risk assessment. PBPK models are mathematical representations of the anatomy, physiology and biochemistry of an organism. ... -
Development of a Framework for Identifying Critical Input Parameters for Effective Pediatric PBPK/PBTK Modelling
(University of Waterloo, 2023-01-20)Within a physiologically based pharmacokinetic (PBPK) model framework, virtual children are built based on known trajectories of anatomy and physiology across age and a compounds transfer within the body is defined by ... -
Development of a Novel, Microemulsion System for the Simultaneous Delivery of Hydrophilic and Hydrophobic Active Pharmaceutical Ingredients (APIs)
(University of Waterloo, 2020-09-28)Concurrent chronic disease and ensuing multi-morbidity are a debilitating reality for millions of Canadians. This adversity is compounded by increased pill burden and decreased patient adherence. Microemulsions (MEs) serve ... -
Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo): Study Protocol
(JMIR Publications, 2016-12-15)Background: Individual pharmacokinetic assessment is a critical component of tailored prophylaxis for hemophilia patients. Population pharmacokinetics allows using individual sparse data, thus simplifying individual ... -
Development of in vitro 3D model systems for screening non-viral neurotrophic factor gene therapies for the retina
(University of Waterloo, 2018-08-21)Glaucoma is a neurodegenerative disease that can lead to a complete loss of vision due to retinal ganglion cell (RGC) death. Therapies that have the capacity to protect and rescue stressed RGCs remain a critical unmet need ... -
Development of Novel Molecules as Modulators of Amyloid-β Aggregation
(University of Waterloo, 2021-09-08)Our brain is remarkably special and unique. It has billions of neurons that govern actions and reactions, and enables us to have thoughts, memories, and personality traits – outmost precious assets – that define who we are ... -
Development of Peptide-Modified Gemini Nanoplexes for Gene Delivery to the Retina
(University of Waterloo, 2020-04-22)Glaucoma is a retinal neurodegenerative disease where the retinal ganglion cells (RGCs) suffer from damage and die over time due to multiple factors, including a persistently elevated intraocular pressure (IOP). Glaucoma ... -
Droplet Microfluidic System with On-Demand Trapping and Releasing of Droplet for Drug Screening Applications
(American Chemical Society (ACS), 2017-01-03)96-Well plate has been the traditional method used for screening drug compounds libraries for potential bioactivity. Although this method has been proven successful in testing doseÐresponse analysis, the microliter consumption ... -
Dynamic mechanical behaviour of nanoparticle loaded biodegradable PVA films for vaginal drug delivery
(Sage Publishing, 2018-03-01)In this study, we investigated the viscoelastic and mechanical behaviour of polyvinyl alcohol films formulated along with carrageenan, plasticizing agents (polyethylene glycol and glycerol), and when loaded with nanoparticles ... -
Effect of a Mobile Phone Intervention on Quitting Smoking in a Young Adult Population of Smokers: Randomized Controlled Trial
(JMIR, 2018-10-23)Background: Digital mobile technology presents a promising medium for reaching young adults with smoking cessation interventions because they are the heaviest users of this technology. Objective: The aim of this study ... -
The Effect of a Source Change for an Active Pharmaceutical Ingredient (API) or Excipient on the Finished Drug Product
(University of Waterloo, 2016-08-10)The global cost of health care is increasing year after year, and one of the ways governments and health care providers are looking to reduce cost is by reducing the cost of drug products. The generic industry is under ... -
Effect of Gemini Surfactants on Amyloid Beta Aggregation
(University of Waterloo, 2013-09-27)Alzheimer’s disease (AD) is a progressive dementia affecting cognition, behavior, and functional status and there is no cure which exists for it. In AD, Amyloid Beta (Aβ) peptides form aggregates that are neurotoxic in the ... -
The Effects of Autophagic Deficiencies on the Leukemia Mitochondrial Phenotype and Implications in Strategic Drug Targeting
(University of Waterloo, 2016-12-13)Acute myeloid leukemia (AML) is a cancer that develops when hematopoietic stem cells in the bone marrow transform into malignant cells and subsequently grow and replicate aberrantly. Autophagy, a pathway by which cellular ...