Browsing Pharmacy by Title
Now showing items 111-130 of 137
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Physician and Pharmacist Medication Decision-Making in the Time of Electronic Health Records: Mixed-Methods Study
(JMIR, 2018-07)Background: Primary care needs to be patient-centered, integrated, and interprofessional to help patients with complex needs manage the burden of medication-related problems. Considering the growing problem of polypharmacy, ... -
Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Children
(University of Waterloo, 2021-06-25)The following thesis chapters chronicle evolving efforts throughout 2016 – 2021 to support research toward improving the pediatric clinical pharmacology of monoclonal antibodies (mAbs). Translating the benefits of successful ... -
Physiologically-based pharmacokinetic model for ciprofloxacin in children with complicated urinary tract infection
(Elsevier, 2019-02-01)In a recent multicenter population pharmacokinetic study of ciprofloxacin administered to children suffering from complicated urinary tract infection (cUTI), the apparent volume of distribution (V) and total plasma clearance ... -
A Picture is Worth a Thousand Words: A Randomized Controlled Trial to Assess the Impact of a Computerized Pictorial Medication Calendar Medication Taking Behaviour
(University of Waterloo, 2017-08-11)OBJECTIVES The primary was to determine if a pictorial medication calendar would improve patient adherence to supportive medication regimens for adult patients receiving chemotherapy treatment. The secondary objectives ... -
Piperine Derivatives as Modulators of Amyloid-Beta (Aβ) Aggregation
(University of Waterloo, 2023-07-12)Alzheimer’s Disease (AD) is a life-changing neurodegenerative disease that progresses in stages and currently has no effective cure. More than 597,000 Canadians suffer from AD. Symptoms of late-stage AD are severe and ... -
Pluronic-Based Nanoparticles for Gene Therapy Applications
(University of Waterloo, 2014-01-24)Non-viral delivery vectors have potential advantages over the viral systems that currently are used extensively for delivering therapeutic genes of interest. However, non-viral gene therapy has low efficiencies in vivo, ... -
Potential of surface modified exosomes for extended intravitreal drug delivery
(University of Waterloo, 2021-04-30)Diabetic retinopathy is a serious condition affecting retinal cells that can lead to blindness. Intravitreal injection is the only feasible method of drug delivery to the retina. However, intravitreal injections are only ... -
Prevalence of Potentially Inappropriate Medications Use Among Recently Admitted Geriatric Patients in Rural Hospitals
(University of Waterloo, 2014-12-11)Potentially inappropriate medications (PIMs) are prescribed most often to elderly patients and can cause serious adverse effects. Older adults tend to use multiple medications, and age-related physiological changes can ... -
Probing the interactions that drive RNA binding and self-association of hnRNPA1 implicated in neurodegeneration
(University of Waterloo, 2024-01-17)The heteronuclear ribonucleoprotein A1 (hnRNPA1 or A1) is associated with the pathology of different diseases, including neurological disorders and cancers. In particular, the aggregation and dysfunction of A1 has been ... -
Procedure-specific Risks of Thrombosis and Bleeding in Urological Non-cancer Surgery: Systematic Review and Meta-analysis
(Elsevier, 2018-02-01)Context Pharmacological thromboprophylaxis involves a trade-off between a reduction in venous thromboembolism (VTE) and increased bleeding. No guidance specific for procedure and patient factors exists in urology. Objective ... -
A Quality Assurance Evaluation of Hydromorphone Adverse Events Post-Implementation of a Safety Initiative
(University of Waterloo, 2019-08)Purpose: Hydromorphone is a potent opioid that may lead to respiratory and central nervous system depression prompting naloxone use. The primary objective of this study was to evaluate whether a safety initiative implemented ... -
Risk and Benefit of Warfarin for Primary Prevention in Atrial Fibrillation Patients on Hemodialysis: A Retrospective Pilot Study
(University of Waterloo, 2020-07-17)Background Despite increased awareness and advocacy regarding the opioid epidemic, data from Health Quality Ontario (HQO) shows steady prescribing of opioids with concerning trends toward prescribing more potent opioids. ... -
Risk and Benefit of Warfarin for Primary Prevention in Atrial Fibrillation Patients on Hemodialysis: A Retrospective Pilot Study
(University of Waterloo, 2019-07)Rationale: Although warfarin is an established anticoagulation therapy for prevention of ischemic strokes in patients with atrial fibrillation, studies reporting INR values with correlation to warfarin efficacy and safety ... -
The risk of fragility fractures in new users of dipeptidyl peptidase-4 inhibitors compared to sulfonylureas and other anti-diabetic drugs: A cohort study
(Elsevier, 2018-02-01)Aims Mixed evidence exists for the effect of incretin-based therapies on osteoporosis in type-2 diabetes. Therefore, we conducted a cohort study to determine the association between dipeptidyl peptidase-4 (DPP-4) inhibitors ... -
The risk of fragility fractures in new users of dipeptidyl peptidase-4 inhibitors compared to sulfonylureas and other anti-diabetic drugs: A cohort study
(Elsevier, 2018-02-01)Aims Mixed evidence exists for the effect of incretin-based therapies on osteoporosis in type-2 diabetes. Therefore, we conducted a cohort study to determine the association between dipeptidyl peptidase-4 (DPP-4) inhibitors ... -
Role of Prolyl 4-Hydroxylase in Pancreatic ß-cell Insulin Secretion
(University of Waterloo, 2017-08-30)Type 2 diabetes mellitus (T2D) is characterized by chronic hyperglycemia and peripheral insulin resistance. In response to elevated blood glucose levels, pancreatic β-cells release insulin which occurs in a biphasic ... -
A Scoping Review of Frailty and Acute Care in Middle-Aged and Older Individuals with Recommendations for Future Research
(Canadian Geriatrics Society, 2017-03-31)There is general agreement that frailty is a state of heightened vulnerability to stressors arising from impairments in multiple systems leading to declines in homeostatic reserve and resiliency, but unresolved issues ... -
Serious Games on the Lived Experience of Dementia as Learning Tools in Pharmacy Education
(University of Waterloo, 2023-10-23)Dementia is a stigmatized and often ‘invisible’ condition which requires clinicians to have a nuanced understanding of the lived experience to build trust and provide better quality of care. Pharmacists are at the frontline ... -
Sex differences in solute and water handling in the human kidney: Modeling and functional implications
(Elsevier, 2021-06)The kidneys maintain homeostasis by controlling the amount of water and electrolytes in the blood. That function is accomplished by the nephrons, which transform glomerular filtrate into urine by a transport process mediated ... -
Shades of gray in vaccine decision making: Understanding, exploring, and addressing the challenges of influenza vaccine hesitancy in Ontario community pharmacies
(University of Waterloo, 2019-12-19)Background: Two-thirds of Canadian adults currently do not receive the annual influenza vaccine. Vaccine hesitancy (VH), the voluntary delay or refusal of vaccination services despite availability is a significant contributor ...