Browsing Pharmacy by Title
Now showing items 105-124 of 137
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Perspectives from Pharmacists, Prescribers and Patients on Sharing Medication Reason for Use
(University of Waterloo, 2020-05-05)Pharmacists rarely receive the reason a medication was prescribed, often referred to as reason for use (RFU). Pharmacists can use this information to better counsel patients, support patients in taking medications safely, ... -
Pharmacist experience with providing care for patients with chronic pain in the community setting: A qualitative study
(University of Waterloo, 2017-01-20)Objectives: Chronic pain is a condition pharmacists frequently encounter in practice; however, the pharmacist’s role in the management of chronic pain is under-investigated. This study examines pharmacist perceptions and ... -
Pharmacokinetic and economic implications when switching between hemophilia A treatments
(University of Waterloo, 2023-04-18)Hemophilia is a bleeding disorder in which the blood is unable to form clots, and is also classified as severe (defined as having an endogenous factor VIII [FVIII] concentration < 1 IU/dL, or 1%), moderate (1-5%) or mild ... -
Pharmacokinetic modelling of clinically relevant situations in the treatment of hemophilia A and B
(University of Waterloo, 2020-04-03)Hemophilia is a congenital bleeding disorder caused by deficiency of clotting factor VIII (FVIII; hemophilia A) or IX (FIX; hemophilia B). Severe hemophilia patients have less than 1% (or 1 IU/dL) of normal factor activity, ... -
Pharmacy patron perspectives of community pharmacist administered influenza vaccinations
(Elsevier, 2019-02)One approach to boost influenza vaccination coverage has been to expand immunization authority. In 2012, the province of Ontario gave community pharmacists the authority to administer the influenza vaccine. -
Pharmacy5in5: Evaluating a computer-based education platform to improve pharmacists’ knowledge and behaviour
(University of Waterloo, 2022-05-30)Background The pharmacist’s role continues to evolve and expand from the traditional role of dispensing to a more patient-centered model of care. However, many pharmacists still fall short in terms of their provision of ... -
Physician and Pharmacist Medication Decision-Making in the Time of Electronic Health Records: Mixed-Methods Study
(JMIR, 2018-07)Background: Primary care needs to be patient-centered, integrated, and interprofessional to help patients with complex needs manage the burden of medication-related problems. Considering the growing problem of polypharmacy, ... -
Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Children
(University of Waterloo, 2021-06-25)The following thesis chapters chronicle evolving efforts throughout 2016 – 2021 to support research toward improving the pediatric clinical pharmacology of monoclonal antibodies (mAbs). Translating the benefits of successful ... -
Physiologically-based pharmacokinetic model for ciprofloxacin in children with complicated urinary tract infection
(Elsevier, 2019-02-01)In a recent multicenter population pharmacokinetic study of ciprofloxacin administered to children suffering from complicated urinary tract infection (cUTI), the apparent volume of distribution (V) and total plasma clearance ... -
A Picture is Worth a Thousand Words: A Randomized Controlled Trial to Assess the Impact of a Computerized Pictorial Medication Calendar Medication Taking Behaviour
(University of Waterloo, 2017-08-11)OBJECTIVES The primary was to determine if a pictorial medication calendar would improve patient adherence to supportive medication regimens for adult patients receiving chemotherapy treatment. The secondary objectives ... -
Piperine Derivatives as Modulators of Amyloid-Beta (Aβ) Aggregation
(University of Waterloo, 2023-07-12)Alzheimer’s Disease (AD) is a life-changing neurodegenerative disease that progresses in stages and currently has no effective cure. More than 597,000 Canadians suffer from AD. Symptoms of late-stage AD are severe and ... -
Pluronic-Based Nanoparticles for Gene Therapy Applications
(University of Waterloo, 2014-01-24)Non-viral delivery vectors have potential advantages over the viral systems that currently are used extensively for delivering therapeutic genes of interest. However, non-viral gene therapy has low efficiencies in vivo, ... -
Potential of surface modified exosomes for extended intravitreal drug delivery
(University of Waterloo, 2021-04-30)Diabetic retinopathy is a serious condition affecting retinal cells that can lead to blindness. Intravitreal injection is the only feasible method of drug delivery to the retina. However, intravitreal injections are only ... -
Prevalence of Potentially Inappropriate Medications Use Among Recently Admitted Geriatric Patients in Rural Hospitals
(University of Waterloo, 2014-12-11)Potentially inappropriate medications (PIMs) are prescribed most often to elderly patients and can cause serious adverse effects. Older adults tend to use multiple medications, and age-related physiological changes can ... -
Probing the interactions that drive RNA binding and self-association of hnRNPA1 implicated in neurodegeneration
(University of Waterloo, 2024-01-17)The heteronuclear ribonucleoprotein A1 (hnRNPA1 or A1) is associated with the pathology of different diseases, including neurological disorders and cancers. In particular, the aggregation and dysfunction of A1 has been ... -
Procedure-specific Risks of Thrombosis and Bleeding in Urological Non-cancer Surgery: Systematic Review and Meta-analysis
(Elsevier, 2018-02-01)Context Pharmacological thromboprophylaxis involves a trade-off between a reduction in venous thromboembolism (VTE) and increased bleeding. No guidance specific for procedure and patient factors exists in urology. Objective ... -
A Quality Assurance Evaluation of Hydromorphone Adverse Events Post-Implementation of a Safety Initiative
(University of Waterloo, 2019-08)Purpose: Hydromorphone is a potent opioid that may lead to respiratory and central nervous system depression prompting naloxone use. The primary objective of this study was to evaluate whether a safety initiative implemented ... -
Risk and Benefit of Warfarin for Primary Prevention in Atrial Fibrillation Patients on Hemodialysis: A Retrospective Pilot Study
(University of Waterloo, 2020-07-17)Background Despite increased awareness and advocacy regarding the opioid epidemic, data from Health Quality Ontario (HQO) shows steady prescribing of opioids with concerning trends toward prescribing more potent opioids. ... -
Risk and Benefit of Warfarin for Primary Prevention in Atrial Fibrillation Patients on Hemodialysis: A Retrospective Pilot Study
(University of Waterloo, 2019-07)Rationale: Although warfarin is an established anticoagulation therapy for prevention of ischemic strokes in patients with atrial fibrillation, studies reporting INR values with correlation to warfarin efficacy and safety ... -
The risk of fragility fractures in new users of dipeptidyl peptidase-4 inhibitors compared to sulfonylureas and other anti-diabetic drugs: A cohort study
(Elsevier, 2018-02-01)Aims Mixed evidence exists for the effect of incretin-based therapies on osteoporosis in type-2 diabetes. Therefore, we conducted a cohort study to determine the association between dipeptidyl peptidase-4 (DPP-4) inhibitors ...