Browsing Pharmacy by Title
Now showing items 64-83 of 127
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Health and Economic Impact of Treatment-based Strategies on Chronic Hepatitis B in Ontario
(University of Waterloo, 2019-08-23)Background/Aim: The lives of about 257 million people in the world are being affected by chronic hepatitis B (CHB), and this contagious disease is gradually pushing them closer to the edge of death caused by cirrhosis and ... -
“I gained a skill and a change in attitude”: A Case Study Describing How an Online Continuing Professional Education Course for Pharmacists Supported Achievement of Its Transfer-to-Practice Outcomes
(The Canadian Association for University Continuing Education, 2014-11-27)The convenience and flexibility of online learning clearly make it an attractive option for learners in professional development contexts. There is less clarity, however, about how it fares as a vehicle for enabling the ... -
Identifying signaling differences between GPCR-induced growth factor receptor transactivation and direct ligand activation
(University of Waterloo, 2014-04-01)Growth factor receptors have significant effects on various normal function of body such as cell proliferation, differentiation and apoptosis. They are also involved in neuronal function and dysfunction, cardiovascular ... -
Identifying the mechanism of Aβ42 inhibition of PDGF-BB signalling
(University of Waterloo, 2014-01-23)Alzheimer’s disease is a late-onset neurological disorder characterized by extracellular aggregates of Aβ plaques and neurofibrillary tangles of hyperphosphoryated tau protein resulting in neuronal dysfunction, cognitive ... -
Immunogenicity and antitumor activity of the superlytic λF7 phage nanoparticles displaying a HER2/neu-derived peptide AE37 in a tumor model of BALB/c mice
(Elsevier, 2018-06-28)Phage display technique has been increasingly researched for vaccine design and delivery strategies in recent years. In this study, the AE37 (Ii-Key/HER-2/neu 776–790) peptide derived from HER2 (human epidermal growth ... -
The impact of prescription medication cost coverage on optimal adherence to Hypertension and Diabetes Mellitus oral medications
(University of Waterloo, 2018-02-26)Background: It can be difficult for patients who do not have prescription medication cost coverage to adhere to their medications. No previous study has examined the time-trend and impact of absence of coverage on adherence ... -
Impact of sex and pathophysiology on optimal drug choice in hypertensive rats: Quantitative insights for precision medicine
(Elsevier, 2021-04)Less than half of all hypertensive patients receiving treatment are successful in normalizing their blood pressure. Despite the complexity and heterogeneity of hypertension, the current antihypertensive guidelines are not ... -
Implant delivering hydroxychloroquine attenuates vaginal T lymphocyte activation and inflammation
(Elsevier, 2018-05-10)Evidence suggests that women who are naturally resistant to HIV infection exhibit low baseline immune activation at the female genital tract (FGT). This “immune quiescent” state is associated with lower expression of T-cell ... -
Improving the delivery and immunogenicity of an inhalable CpG-ODN DNA vaccine by bio-adhesive gemini nanoparticles in neonatal chickens
(University of Waterloo, 2018-01-05)Cytosine-phosphodiester-guanine oligodeoxynucleotides (CpG-ODN) are nucleotide sequence motifs found in the bacterial genome that activate the mammalian innate immune response and have been found to boost humoral immunity ... -
In-Silico Methods for De-Risking the Clinical Development of Subcutaneously Administered Therapeutic Macromolecules
(University of Waterloo, 2016-07-27)Prediction of human pharmacokinetics (PK) following subcutaneous (SC) administration to animals is challenged by potential interspecies differences in skin anatomy and physiology. With respect to biologic or macromolecule ... -
In-solution and physical state properties of polymer and lipid excipients and their effects on the supersaturation evolution of poorly water-soluble drugs
(University of Waterloo, 2023-04-14)Solubility has become an increasing issue for the pharmaceutical industry, as the advances in combinatorial chemistry and high throughput screening methods have resulted in an increase in the molecular weight and lipophilicity ... -
Incorporating sex, gender and vulnerable populations in a large multisite health research programme: The Ontario Pharmacy Evidence Network as a case study
(BioMed Central, 2017-03-20)Background: Funders now frequently require that sex and gender be considered in research programmes, but provide little guidance about how this can be accomplished, especially in large research programmes. The purpose of ... -
Integration of Smart Multidose Blister Packaging for Medication Management
(University of Waterloo, 2022-04-26)Medication non-adherence can lead to non-optimal management of chronic diseases and poor health outcomes. Numerous innovative dispensing products offering real-time medication intake monitoring are being developed and ... -
The Interplay Between the Neuronal Plasma Membrane and Cell Signaling in Alzheimer’s Disease
(University of Waterloo, 2023-03-10)The lack of understanding in the molecular and cellular mechanisms of Alzheimer’s disease (AD) has hindered efforts towards finding treatments that effectively modify disease trajectory. Therapeutic development for AD has ... -
Investigating the Interactions of Fatty Acids, Amyloid Beta & SARS-CoV-2 Spike Protein Fragment
(University of Waterloo, 2023-05-16)There is no cure for Alzheimer’s disease (AD), and the negative implications of having AD were further exacerbated in recent years, as patients with dementia are at the highest risk for mortality upon contracting COVID-19. ... -
Investigating the neuroprotective potential of short-term 5-HT7 receptor activation against neuronal excitotoxicity
(University of Waterloo, 2015-10-05)The pathophysiology of cerebral ischemia or acute ischemic stroke involves what is called neuronal "excitotoxicity", where an initial failure in intracellular energy metabolism causes excessive pre-synaptic glutamate release ... -
Isolation and Characterization of Host Mutations that Suppress the Bacteriophage Lambda (λ) Rex Phenotype
(University of Waterloo, 2015-09-01)The Bacteriophage lambda (λ) T4rII exclusion (Rex) phenotype is defined as the inability of T4rII mutant bacteriophage to form plaques on a lawn of E. coli lysogenized by bacteriophage λ. More than six decades have passed ... -
Lack of neuroprotective effects by platelet-derived growth factor against beta-amyloid induced toxicity uncovers a novel hypothesis of Alzheimer's disease pathology
(University of Waterloo, 2012-05-18)Aβ oligomer-induced neurotoxicity has become an important area of therapeutic development in treating Alzheimer’s disease. Platelet-derived growth factor (PDGF) has been shown to be able to protect neurons against several ... -
Langmuir-Blodgett Monolayer Studies of Mixed Gemini Surfactant-Phospholipid Monolayers system for Gene Therapy Applications.
(University of Waterloo, 2015-10-23)Gene delivery relies upon the encapsulation of a gene of interest, which is then ideally delivered to target cells. For gene therapy applications, viral vectors are the most efficient vectors currently being studied, ... -
Metabolism, transport, and physiologically based pharmacokinetic modelling of novel tacrine derivatives
(University of Waterloo, 2015-08-26)Alzheimer’s disease (AD) is the most prevalent form of dementia affecting the elderly population, and its burden is rapidly growing both in Canada and worldwide. As a result, there is a substantial need for more effective ...