Browsing Pharmacy by Title
Now showing items 50-69 of 127
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Effect of a Mobile Phone Intervention on Quitting Smoking in a Young Adult Population of Smokers: Randomized Controlled Trial
(JMIR, 2018-10-23)Background: Digital mobile technology presents a promising medium for reaching young adults with smoking cessation interventions because they are the heaviest users of this technology. Objective: The aim of this study ... -
The Effect of a Source Change for an Active Pharmaceutical Ingredient (API) or Excipient on the Finished Drug Product
(University of Waterloo, 2016-08-10)The global cost of health care is increasing year after year, and one of the ways governments and health care providers are looking to reduce cost is by reducing the cost of drug products. The generic industry is under ... -
Effect of Gemini Surfactants on Amyloid Beta Aggregation
(University of Waterloo, 2013-09-27)Alzheimer’s disease (AD) is a progressive dementia affecting cognition, behavior, and functional status and there is no cure which exists for it. In AD, Amyloid Beta (Aβ) peptides form aggregates that are neurotoxic in the ... -
The Effects of Autophagic Deficiencies on the Leukemia Mitochondrial Phenotype and Implications in Strategic Drug Targeting
(University of Waterloo, 2016-12-13)Acute myeloid leukemia (AML) is a cancer that develops when hematopoietic stem cells in the bone marrow transform into malignant cells and subsequently grow and replicate aberrantly. Autophagy, a pathway by which cellular ... -
Endocannabinoids as Amyloid-Beta (Aβ) Aggregation Inhibitors
(University of Waterloo, 2022-05-13)The endocannabinoid system, including endogenous cannabinoids and their corresponding receptors, has received extensive attention in the last few years for their neuroprotective effect in the central nervous system. The ... -
Ethynyl-1,1’-Biphenyl Derivatives as Amyloid Beta Aggregation Inhibitors
(University of Waterloo, 2019-12-19)Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder, with characteristic symptoms including memory loss and cognitive decline. AD is characterized by the formation of dense amyloid β (Aβ) plaques and ... -
Evaluating Nutraceuticals for Selective Toxicity Toward Leukemia Stem Cells
(University of Waterloo, 2015-05-22)Targeting leukemia stem cells (LSCs) is critical to improving the poor outcome of acute myeloid leukemia (AML) patients. Nutraceuticals (i.e., food derived bioactive compounds) provide a wealthy resource for novel ... -
Evaluating the anti-leukemia activity of avocatin B
(University of Waterloo, 2015-01-15)Acute myeloid leukemia (AML) is an aggressive malignant disease characterized by poor patient outcome and suboptimal front-line chemotherapy. To identify novel anti-AML compounds, a high-throughput screen of a natural ... -
Evaluating the Usability of a Medication Organizing Tool on Home Medication Management - A Proof-of-Concept Experiment
(University of Waterloo, 2015-02-20)Background: Chronic disease and medication self-management is a life-long process in which patient self-efficacy plays an important role in determining success. Efforts to improve self-management have traditionally focused ... -
Evaluation of a microlearning module on hypertension in Canada
(University of Waterloo, 2023-02-20)Objectives: To use a microlearning platform to evaluate pharmacists’ knowledge and behaviour related to hypertension. Methods: Pharmacy 5in5 is an online microlearning platform designed to help pharmacy professionals ... -
An Evaluation of the Effect of Primary Care Pharmacist Interventions on Patients with Chronic Pain
(University of Waterloo, 2017-01-20)Background: Chronic pain is a common condition that has significant impact on patients’ physical and psychological well-being. Pharmacotherapeutic management of chronic pain differs on the basis of the cause pain. ... -
Exploring the role of teams and technology in patients' medication decision making
(Elsevier, 2019-03)We know little about how electronic health records (EHRs) should be designed to help patients, pharmacists, and physicians participate in interprofessional shared decision making. We used a qualitative approach to understand ... -
Glucopsychosine increases cytosolic calcium to induce calpain-mediated apoptosis of acute myeloid leukemia cells.
(University of Waterloo, 2014-08-20)To identify novel anti-cancer agents, we created and screened a unique nutraceutical library for activity against acute myeloid leukemia (AML) cells. From this screen, we determined that glucopsychosine was selectively ... -
GPCR and RTK Regulation in Neurons: The Impact of Stress on GPCR and RTK signalling and Crosstalk
(University of Waterloo, 2020-04-14)Crosstalk between receptors allows for the integration of diverse and complex signalling pathways. Transactivation is a form of crosstalk between G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). ... -
Health and Economic Impact of Treatment-based Strategies on Chronic Hepatitis B in Ontario
(University of Waterloo, 2019-08-23)Background/Aim: The lives of about 257 million people in the world are being affected by chronic hepatitis B (CHB), and this contagious disease is gradually pushing them closer to the edge of death caused by cirrhosis and ... -
“I gained a skill and a change in attitude”: A Case Study Describing How an Online Continuing Professional Education Course for Pharmacists Supported Achievement of Its Transfer-to-Practice Outcomes
(The Canadian Association for University Continuing Education, 2014-11-27)The convenience and flexibility of online learning clearly make it an attractive option for learners in professional development contexts. There is less clarity, however, about how it fares as a vehicle for enabling the ... -
Identifying signaling differences between GPCR-induced growth factor receptor transactivation and direct ligand activation
(University of Waterloo, 2014-04-01)Growth factor receptors have significant effects on various normal function of body such as cell proliferation, differentiation and apoptosis. They are also involved in neuronal function and dysfunction, cardiovascular ... -
Identifying the mechanism of Aβ42 inhibition of PDGF-BB signalling
(University of Waterloo, 2014-01-23)Alzheimer’s disease is a late-onset neurological disorder characterized by extracellular aggregates of Aβ plaques and neurofibrillary tangles of hyperphosphoryated tau protein resulting in neuronal dysfunction, cognitive ... -
Immunogenicity and antitumor activity of the superlytic λF7 phage nanoparticles displaying a HER2/neu-derived peptide AE37 in a tumor model of BALB/c mice
(Elsevier, 2018-06-28)Phage display technique has been increasingly researched for vaccine design and delivery strategies in recent years. In this study, the AE37 (Ii-Key/HER-2/neu 776–790) peptide derived from HER2 (human epidermal growth ... -
The impact of prescription medication cost coverage on optimal adherence to Hypertension and Diabetes Mellitus oral medications
(University of Waterloo, 2018-02-26)Background: It can be difficult for patients who do not have prescription medication cost coverage to adhere to their medications. No previous study has examined the time-trend and impact of absence of coverage on adherence ...