Browsing Optometry and Vision Science by Subject "Vision Science and Biology"
Now showing items 1-11 of 11
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Cell death and proliferation characteristics of the retina after optic nerve section in chickens
(University of Waterloo, 2013-09-27)Optic nerve section (ONS) is an experimental model for damage of the optic nerve associated with diseases such as glaucoma and optic neuritis. Damage to the optic nerve causes loss of retinal ganglion cells that are ... -
Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products
(University of Waterloo, 2009-04-27)The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty ... -
The Effects of 1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7) on the Lens During Avian Accommodation In Situ
(University of Waterloo, 2009-12-17)A previous study in chickens revealed that myosin light chain kinase (MLCK), f actin, and myosin are found on the crystalline lens. Their polygonal arrangement at the posterior surface resembles a muscle tissue, which ... -
Fish (Oreochromis niloticus) as a Model of Refractive Error Development
(University of Waterloo, 2009-01-13)Myopia is a common ocular condition worldwide and the mechanism of myopia is still not clear. A number of animal models of myopia and refractive error development have been proposed. The fact that form deprivation myopia ... -
Fundamentals of Protein Adsorption at the Solid-Liquid Interface over Short Time Periods
(University of Waterloo, 2014-12-16)Purpose: To directly measure the quantity and degree of denaturation of biomaterial- adsorbed proteins over short time periods. Methods: Contact lenses were used as model biomaterials as they are widely used, readily ... -
Investigations on the Reptilian Spectacle
(University of Waterloo, 2012-12-12)The eyes of snakes and most geckos, as well as a number of other disparate squamate taxa, are shielded beneath a layer of transparent integument referred to as the “reptilian spectacle.” Derived from the embryonic fusion ... -
Mitochondrial Function and Optical Properties of the Crystalline Lens
(University of Waterloo, 2009-01-15)The crystalline lens is a unique cellular organ that performs metabolic processes while maintaining optical functionality. Mitochondria play a vital role in providing the cell with the energy necessary for these metabolic ... -
Retinal degeneration in and in vivo electroretinography measurements of Smoky Joe Chickens
(University of Waterloo, 2012-09-28)Inherited retinal degenerative diseases can affect various components of the retina leading to blindness. Five different mutant strains of chicken have been studied extensively as potential models for inherited retinal ... -
The Role of MMPs, Smad3 and Heat Shock Proteins in TGF-β-Induced Anterior Subcapsular Cataract Development
(University of Waterloo, 2007-06-18)Transforming growth factor beta (TGF-β) has been implicated in anterior subcapsular cataract (ASC) development. In the first section of this thesis, an in-vitro rat lens model was used to determine the role of matrix ... -
Toxicity of Ophthalmic Solutions, Benzalkonium Chloride and UV Radiation on Human Corneal Epithelial Cells in vitro
(University of Waterloo, 2015-06-12)The purpose of this work was to develop a sensitive in vitro method for ocular toxicity testing; and to use this method to assess the individual and combined effects of ophthalmic solutions, benzalkonium chloride (BAK), ... -
Ultraviolet B and blue light - induced phototoxic effects on retinal pigment epithelium using in vitro assays
(University of Waterloo, 2008-09-12)It is well known that ultraviolet (UV) B (280-315 nm) and blue light (400-500 nm) radiation can produce phototoxic lesions in the neural retina and the retinal pigment epithelium (RPE). In the first section of this thesis, ...