Browsing Optometry and Vision Science by Title
Now showing items 192-211 of 246
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Retinal and Optic Nerve Head Vascular Reactivity in Primary Open Angle Glaucoma
(University of Waterloo, 2009-05-14)The global aim of this thesis was to assess retinal vascular reactivity in glaucoma patients using a standardised hypercapnic stimulus. There is a suggestion of disturbance in the regulation of retinal and optic nerve head ... -
Retinal Blood Flow and Markers of Vascular Inflammation and Endothelial Dysfunction in Type 2 Diabetes
(University of Waterloo, 2010-09-01)Abnormal leukocyte adhesion (i.e. leukostasis) to retinal vascular endothelial cells occurs in early diabetes. The processes of leukostasis have been clearly demonstrated in the vascular endothelium of patients with diabetes. ... -
Retinal Blood Flow and Vascular Reactivity in Chronic Smokers
(University of Waterloo, 2013-02-25)Purpose To investigate the impact of cigarrete smoking in a group of otherwise healthy young individuals on: 1) Retinal blood flow using Doppler based SD-OCT, 2) Retinal vascular reactivity using a gas sequencer to ... -
Retinal Blood Flow and Vascular Reactivity in Diabetic Retinopathy
(University of Waterloo, 2006-12-18)Introduction Retinal vascular reactivity is impaired in patients with diabetes and is thought to be involved in the onset and progression of diabetic retinopathy (DR). Previous studies that have utilized hyperoxia to ... -
Retinal Blood Oxygen Saturation and Angiogenic and Inflammatory Biomarkers in Type 2 Diabetes
(University of Waterloo, 2015-01-16)Introduction: Diabetic retinopathy (DR) is a major source of visual loss in the world, including North America. A number of hyperglycemia-related pathways have been associated with DR onset and progression. Disturbances ... -
Retinal degeneration in and in vivo electroretinography measurements of Smoky Joe Chickens
(University of Waterloo, 2012-09-28)Inherited retinal degenerative diseases can affect various components of the retina leading to blindness. Five different mutant strains of chicken have been studied extensively as potential models for inherited retinal ... -
Retinal Haemodynamics in Primary Open Angle Glaucoma Patients with Differing Nocturnal Blood Pressure Profiles
(University of Waterloo, 2014-08-14)The impairment of ocular haemodynamics has been reported in primary open angle glaucoma (POAG) patients using various blood flow measurement techniques. Studies have shown hypotension may accelerate progression in POAG and ... -
Retinal Imaging: Acquisition, Processing, and Application of Mueller Matrix Confocal Scanning Laser Polarimetry
(University of Waterloo, 2013-05-28)The focus of this thesis is the improvement of acquisition and processing of Mueller matrix polarimetry using a confocal scanning laser ophthalmoscope (CSLO) and the application of Mueller matrix polarimetry to image the ... -
Retinal perfusion changes in radiation retinopathy-post brachytherapy for choroidal melanoma
(University of Waterloo, 2017-04-21)Introduction: Radiation retinopathy (RR) is a chronic progressive vasculopathy developing secondary to the impact of ionizing radiation to the retina. RR develops post radiation therapy using radioactive plaque to treat ... -
Retinal Structure and Function in Typical Children and Young Adults
(University of Waterloo, 2021-01-20)Purpose. Children with visual impairment may be referred for ERG and OCT testing to aid in diagnosis and monitoring, particularly those with suspected retinal diseases. To establish if a result is abnormal, knowledge of ... -
Retinal Vascular Reactivity to Incremental Hyperoxia During Isocapnia
(University of Waterloo, 2008-07-07)PURPOSE: Systemic hyperoxia has been induced using inspired gases in many studies to investigate vascular reactivity in the retinal vasculature. Technical limitations in the past resulted in inadequate control of systemic ... -
The Role of MMPs, Smad3 and Heat Shock Proteins in TGF-β-Induced Anterior Subcapsular Cataract Development
(University of Waterloo, 2007-06-18)Transforming growth factor beta (TGF-β) has been implicated in anterior subcapsular cataract (ASC) development. In the first section of this thesis, an in-vitro rat lens model was used to determine the role of matrix ... -
Self versus examiner administration of the Ocular Surface Disease Index©
(Elsevier, 2017-01)Purpose: To compare the difference in Ocular Surface Disease Index© (OSDI) scores when participants were given the OSDI to complete on their own (self-guided, SG), versus under the guidance of the examiner (examiner-guided, ... -
Sensitivity Across the Ocular Surface—Fundamental Findings and Clinical Applications
(University of Waterloo, 2010-04-29)Current understanding of sensitivity and sensation experienced across the ocular surface remains limited. This project explored the regional variation of corneal sensitivity and transducer function, interaction of sensory ... -
Short-Term Moderately Elevated Intraocular Pressure Is Associated With Elevated Scotopic Electroretinogram ResponsesShort-Term Elevated IOP and Scotopic ERG Responses
(Association of Research in Vision and Ophthalmology, 2016-04-01)Moderately elevated intraocular pressure (IOP) is a risk factor for open-angle glaucoma. Some patients suffer glaucoma despite clinically measured normal IOPs. Fluctuations in IOP may have a significant role since IOPs are ... -
Sjogren's Syndrome: A Clinical and Biochemical Analysis
(University of Waterloo, 2009-04-30)Sjogren’s syndrome (SS) is a systemic autoimmune disease that presents to eye care practitioners with the hallmark symptom of “dry eye.” Stratifying dry eye patients as Sjogren’s positive or negative is a critical ... -
Statistical Analysis of Hartmann-Shack Images of a Pre-school Population
(University of Waterloo, 2010-01-22)The impact of uncoordinated growth of the optical components of the eye may stimulate different levels of monochromatic aberrations in the growing eyes of the children. This thesis aimed to examine the impact of age, visual ... -
Stereocoherence thresholds as a measure of global stereopsis
(University of Waterloo, 2017-06-14)Purpose: The purpose of this study was to develop a robust and reliable clinical test of stereopsis that is complementary to the conventional disparity threshold tests. Methods: Random dot stereograms containing ... -
Stimulus characteristics of a novel air-based multiple stimulus aesthesiometer
(University of Waterloo, 2022-01-05)Purpose: To (1) develop a novel air-based aesthesiometer capable of producing and applying multiple stimuli separated either by time or space; (2) identify the stimulus airflow characteristics and confirm the consistency ... -
Structure and Function in Early Glaucoma
(University of Waterloo, 2016-08-24)Glaucoma is a group of diseases, which exhibit a characteristic optic neuropathy and may result in progressive visual field loss. The most important risk factor is raised intraocular pressure (IOP) usually secondary to ...