Browsing Optometry and Vision Science by Author "McCanna, David J."
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Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products
McCanna, David J. (University of Waterloo, 2009-04-27)The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty ... -
In vitro ultraviolet–induced damage in human corneal, lens, and retinal pigment epithelial cells
Youn, Hyun-Yi; McCanna, David J.; Sivak, Jacob G.; Jones, Lyndon W. (Molecular Vision, 2011-01-21)Purpose: The purpose was to develop suitable in vitro methods to detect ocular epithelial cell damage when exposed to UV radiation, in an effort to evaluate UV-absorbing ophthalmic biomaterials.Methods: Human corneal ...