Chemistry: Recent submissions
Now showing items 21-40 of 836
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Aptamer-Based Detection of Caffeine and Theophylline Through Utilization of Gold Nanoparticles and Graphene Oxide
(University of Waterloo, 2023-04-26)The caffeine and theophylline aptamers were used in tandem with gold nanoparticles and graphene oxide to study potential methods for small molecule detection. The AuNP approach is a label-free approach, and the graphene ... -
Temperature Programming of the Second Dimension in Comprehensive Two-Dimensional Gas Chromatography (GC×GC)
(University of Waterloo, 2023-04-10)Comprehensive two-dimensional gas chromatography (GC×GC) is a mature separation technique that is now over three decades old. It separates all sample components using two GC columns with different selectivities, connected ... -
Development of the Synthesis of Thiophene and Thiazole Based Conjugated Polymers Through Direct Arylation and The Separation of Carbon Nanotubes Using Degradable Conjugated Polymers
(University of Waterloo, 2023-01-30)Conjugated polymers are an ever-growing field due to their ability to be used for a variety of purposes such as photovoltaics, field-effect transistors, light emitting diodes, and organic sensors. To further this field, ... -
Optimization of Tin Selenide Thermoelectric Properties
(University of Waterloo, 2023-01-27)The high performance thermoelectric material tin selenide is of notable interest to the field of thermoelectric materials; since breaking the record for being the most efficient thermoelectric material due to the ultralow ... -
Exploration of reconstructed PET hydrolase ancestors by biophysical and computational methods
(University of Waterloo, 2023-01-26)Ancestral sequence reconstruction (ASR), originally developed for the study of molecular evolution, has gained attention as a promising method for protein engineering in the recent decade. The ancestors revived by this ... -
Machine Learning Model for Repurposing Drugs to Target Viral Diseases
(University of Waterloo, 2023-01-26)With recent events, such as the Covid-19 pandemic, it is increasingly important to develop strategies to combat viral diseases. Due to technological advancements, computer-aided drug design and machine learning (ML)-based ... -
Immature SOD1: protein folding, misfolding and aggregation
(University of Waterloo, 2023-01-25)Protein misfolding and aggregation are hallmarks of many diseases, including amyotrophic lateral sclerosis (ALS). In familial ALS, aberrant self-association of mutant Cu,Zn-superoxide dismutase (SOD1) is implicated as a ... -
Development of Advanced Polymer-Soil Composites as High-Performance Construction Materials
(University of Waterloo, 2023-01-23)Construction using earth materials is an old building practice that can be traced back to approximately 10,000 BC. Costs for this type of construction are low because local materials are utilized, and structures are built ... -
Development of 3D Printable, Hydrophilic, and Rapidly Curing Silicone-based Ink Formulations for Various Biomedical Applications
(University of Waterloo, 2023-01-18)3D printing is the use of additive manufacturing techniques to deposit materials layer-by-layer. Compared to alternative tissue fabrication methods such as casting, 3D printing is unique, because it uses CT and MRI scans ... -
Equilibrium and dynamical computation schemes for vibronic models of nonadiabatic systems
(University of Waterloo, 2023-01-06)Two computational schemes were investigated for studying vibronic models of nonadiabatic systems: Path Integral Monte Carlo (PIMC) and vibrational electronic coupled cluster (VECC). A PIMC method was used to investigate ... -
Metal-mediated Adsorption of DNA Oligonucleotides onto Polymeric Materials
(University of Waterloo, 2022-12-20)In recent decades, DNA oligonucleotides have been extensively researched due to their applications for catalysis (DNAzymes), biosensing (DNA aptamers/Watson-Crick hybridization), and nanomaterials assembly (DNA origami). ... -
The Investigation of Isomers using Differential Mobility Spectrometry and Ultraviolet Photodissociation Spectroscopy
(University of Waterloo, 2022-10-26)The analysis of complex mixtures in mass spectrometry (MS) is often complicated by the presence of isomers exhibiting the same mass-to-charge ratios. Tandem MS can simplify isomer analysis and enable ion characterization ... -
Polymer Additive Engineering of Organolead Halide Perovskites: Effect on Device Characteristics and Scalable Manufacturing
(University of Waterloo, 2022-10-21)Within the last decade, organolead halide perovskites such as methylammonium lead iodide (MAPbI₃), have established themselves as a promising material choice for developing highly efficient and cost-effective photosensitive ... -
A Study of Electrochemically Induced Lattice Distortions in Layered Perovskites
(University of Waterloo, 2022-10-05)The intermittency of renewable electricity necessitates the development of energy storage solutions that are rapidly deployable. Solid state devices such as fuel cells, electrolyzers and batteries have could potentially ... -
Engineering the kinetic stability of a β-trefoil protein by tuning its topological complexity
(University of Waterloo, 2022-10-03)Kinetic stability is crucially important for engineering stable proteins suitable for use in industrial, research, and medical applications. Specifically, kinetic stability is central to determining a protein’s functional ... -
Calibrating the Long-Range Backbone Dynamics of Polymers in Solution Using Two Different Models
(University of Waterloo, 2022-09-29)The fluorescence decays of a series of 41 pyrene-labeled poly(oligo(ethylene glycol)methyl ether methacrylate)s (Py-PEGnMA where n = 0, 1, 2, 3, 4, 5, 9, 16, 19) were prepared by free-radical polymerization of 1-pyrenebutyl ... -
Development and Study of the Microfluidic Open Interface Coupled with Solid-phase Microextraction for Rapid Analysis
(University of Waterloo, 2022-09-28)Analytical chemistry mainly aims to identify and quantify analytes in matrices of interest. Analytical chemistry is an indispensable part of chemistry (and other scientific fields) because identification and quantification ... -
Biochemical Characterization of Fluorophore-Binding Nucleic Acids
(University of Waterloo, 2022-09-27)Aptamers, single stranded RNA or DNA that bind to target ligands with high affinity and specificity, have a wide range of applications, from therapeutics to biosensing, which makes biochemical characterization of the utmost ... -
Synthesis and Study of the Cyclic Lipopeptide Antibiotics Daptomycin and A54145
(University of Waterloo, 2022-09-21)Daptomycin (dap) is a clinical antibiotic used to treat infections with multi-drug resistant Gram-positive bacteria. Despite nearly 20 years of clinical use, the action mechanism of this important peptide is not fully ... -
Advances in two-dimensional liquid chromatography
(University of Waterloo, 2022-08-26)Comprehensive two-dimensional liquid chromatography (LC×LC) offers increased peak capacity, resolution and selectivity compared to one-dimensional liquid chromatography. It is commonly accepted that the technique produces ...