Browsing Chemistry by Supervisor "Taylor, Scott"
Now showing items 1-10 of 10
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Daptomycin: studies on its action mode and on bacterial resistance with model membranes
(University of Waterloo, 2016-05-16)Bacterial resistance to antibiotics is one of the most serious problems facing medicine today. Recently, reports have appeared describing bacteria that are resistant to daptomycin (dap), an important antibiotic used against ... -
Lipodepsipeptide Antibiotics: Total Synthesis and Mechanism of Action Studies Using 19F-NMR
(University of Waterloo, 2020-01-24)Daptomycin is a calcium-dependent cyclic lipodepsipeptide that is used clinically in the treatment of infections caused by pathogenic Gram-positive organisms, such as methicillin-resistant Staphylococcus aureus. Another ... -
The Lipopeptide Antibiotic Daptomycin: Its Interaction With Calcium And Membranes And The Effects Of Membrane Lipid Composition On Its Activity
(University of Waterloo, 2018-01-22)Daptomycin (Dap) is a calcium-dependent cyclic lipodepsipeptide antibiotic used clinically to treat infections with pathogenic Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). It targets ... -
Solid-Phase Total Synthesis of Dehydrotryptophan-Bearing Cyclic Peptides Tunicyclin B, Sclerotide A, CDA3a and CDA4a using a Protected β-Hydroxytryptophan Building Block
(University of Waterloo, 2021-05-31)The non-proteinogenic amino acid Z-dehydrotryptophan can be found in a several naturally occurring peptide. Amongst them are cyclic peptides such as tunicyclin B, the antifungal agents keramamide F and sclerotide A, as ... -
Starch-based Polymers as Flocculants of Oil Sands Mature Fine Tailings and for Extraction of Bitumen from Oil Sands
(University of Waterloo, 2020-09-25)Mature fine tailings (MFT) generated by oil sands extraction operations in Alberta pose significant environmental challenges. Polymeric flocculants are often needed to accelerate the consolidation and dewatering of MFT. A ... -
Structure-Activity Relationship Studies on Daptomycin
(University of Waterloo, 2018-08-22)Daptomycin (Dap) is a Ca2+-dependent cyclic lipodepsipeptide antibiotic used for treating skin infections caused by Gram-positive pathogens. It is also used to treat endocarditis caused by Staphylococcus aureus including ... -
Synthesis and Characterization of Thermoresponsive Starch Nanoparticles
(University of Waterloo, 2016-08-31)Thermoresponsive polymers (TRPs) are polymers that exhibit an abrupt change in their physical properties, such as solubility, with a change in temperature. The vast majority of TRPs produced to date are synthetic and ... -
Synthesis and Study of the Cyclic Lipopeptide Antibiotics Paenibacterin and Daptomycin
(University of Waterloo, 2021-09-23)Cyclic lipopeptides present a rich source of antimicrobial compounds with diverse modes of action. Paenibacterin is a cyclic lipopeptide antibiotic produced by Paenibacillus thaminolyticus that exhibits activity against a ... -
Synthesis of ß-Keto-and ß-Hydroxy-α,α-difluorosulfonamides.
(University of Waterloo, 2021-05-28)Abstract ß-Keto- and ß-hydroxy-α,α-difluorosulfonamides are both underexplored classes of molecules. There is only one report of each class of molecules in the literature, however very similar molecules are well known and ... -
Towards the Development of Thermoresponsive Starch Films
(University of Waterloo, 2018-05-22)Wound dressings are an important part of the global wound care market. In addition to having desirable physical properties such as flexibility and gas permeability, it is also important that they be easily removed. As ...