Browsing Chemistry by Title
Now showing items 421-440 of 827
-
Investigations of Bacterial Methionine Aminopeptidase
(University of Waterloo, 2009-10-05)The pathway representing methionine integration and excision is an increasingly important target in drug design. Methionine aminopeptidase (MetAP), a metalloprotease responsible for cleaving the N-terminal methionine from ... -
Investigations of Magnetic Model Systems Using Coupled Cluster Based Approaches
(University of Waterloo, 2017-08-23)Over the past decades, the quantum mechanical description of magnetic phenomena has been well developed. However, the first principle calculations of the physical properties of magnetic systems is still a challenge. One ... -
Investigations of the Natural Product Antibiotic Thiostrepton from Streptomyces azureus and Associated Mechanisms of Resistance
(University of Waterloo, 2013-03-11)The persistence and propagation of bacterial antibiotic resistance presents significant challenges to the treatment of drug resistant bacteria with current antimicrobial chemotherapies, while a dearth in replacements for ... -
Investigations on the Oligomerization of Pyolysin, a Cholesterol-Dependent Cytolysin
(University of Waterloo, 2011-01-25)The bacterial toxin pyolysin (PLO) is a member of the family of Cholesterol-Dependent Cytolysins, which form large, oligomeric pores in cholesterol-containing membranes. The general CDC structure has an elongated shape and ... -
Iron oxide nanozyme catalyzed synthesis of fluorescent polydopamine for light-up Zn2+ detection
(Royal Society of Chemistry, 2016-07-29)Fluorescent polydopamine (FPD) is an interesting material with excellent biocompatibility. However, its preparation is currently a lengthy and potentially dangerous process. We herein employ magnetic iron oxide (Fe3O4) ... -
Kinetics of Deliquescence of Ammonium Sulfate Particles
(University of Waterloo, 2008-05-15)The goal of this project was to study the deliquescence kinetics of aerosol particles of atmospheric significance. In the course of this work a novel experimental method was developed, which utilizes the measurement of the ... -
Label-Free Ag+ Detection by Enhancing DNA Sensitized Tb3+ Luminescence
(Multidisciplinary Digital Publishing Institute, 2016-08-26)In this work, the effect of Ag+ on DNA sensitized Tb3+ luminescence was studied initially using the Ag+-specific RNA-cleaving DNAzyme, Ag10c. While we expected to observe luminescence quenching by Ag+, a significant ... -
Lactate Detection Using Non-Enzymatic Catalytic Materials
(University of Waterloo, 2022-04-29)An Anastomotic leak (AL) can be defined as the leakage of gastrointestinal fluids into the abdominal cavity at the site of an anastomosis. It is a post-operative complication that affects thousands of patients annually ... -
Laser Desorption Solid Phase Microextraction
(University of Waterloo, 2006)The use of laser desorption as a sample introduction method for solid phase microextraction (SPME) has been investigated in this research project. Three different types of analytical instruments, mass spectrometry (MS), ... -
Ligand Specificity and Affinity in the Sulforhodamine B Binding RNA Aptamer
(Elsevier Inc., 2020-07-18)Binding affinity and selectivity are critical properties of aptamers that must be optimized for any application. The sulforhodamine B binding RNA aptamer (SRB‐2) is a somewhat promiscuous aptamer that can bind ligands ... -
LIGAND TRANSFER REACTIONS OF HYPERVALENT IODINE REAGENTS WITH PHOSPHORUS COMPOUNDS
(University of Waterloo, 2018-01-23)Many hypervalent iodine compounds are used as versatile reagents in synthetic organic chemistry. Hypervalent iodine reagents are capable of oxidizing trivalent phosphorus compounds into pentavalent, by transferring their ... -
Light-Activated Metal-Coordinated Supramolecular Complexes with Charge-Directed Self-Assembly
(American Chemical Society, 2013-02-21)Metal-coordinated materials are attractive for many applications including catalysis, sensing, and controlled release. Adenine and its derivatives have been widely used to generate many coordination complexes, polymers, ... -
Lipodepsipeptide Antibiotics: Total Synthesis and Mechanism of Action Studies Using 19F-NMR
(University of Waterloo, 2020-01-24)Daptomycin is a calcium-dependent cyclic lipodepsipeptide that is used clinically in the treatment of infections caused by pathogenic Gram-positive organisms, such as methicillin-resistant Staphylococcus aureus. Another ... -
The Lipopeptide Antibiotic Daptomycin: Its Interaction With Calcium And Membranes And The Effects Of Membrane Lipid Composition On Its Activity
(University of Waterloo, 2018-01-22)Daptomycin (Dap) is a calcium-dependent cyclic lipodepsipeptide antibiotic used clinically to treat infections with pathogenic Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). It targets ... -
Liposome Supported Metal Oxide Nanoparticles: Interaction Mechanism, Light Controlled Content Release and Intracellular Delivery
(Wiley, 2014-05-26)Zwitterionic phosphotydylcholine liposomes stably adsorb a number of metal oxide nanoparticles via its phosphate group. This is different from physisorption and fusion with SiO2. The hybrid materials can be internalized ... -
Liposome/Graphene Oxide Interaction Studied by Isothermal Titration Calorimetry
(American Chemical Society, 2015-03-15)The interaction between graphene oxide (GO) and lipid bilayers is important for fundamental surface science and many applications. In this work, isothermal titration calorimetry (ITC), cryo-TEM, and fluorescence spectroscopy ... -
Lithium ion conducting inorganic solid electrolytes and all solid-state lithium batteries
(University of Waterloo, 2021-11-08)As the world transitions away from fossil energy to green and renewable energy, electrochemical energy storage techniques, especially rechargeable batteries, increasingly become a vital component for this transition. High ... -
Long Range Polymer Chain Dynamics Probed with Pyrene Excimer Fluorescence
(University of Waterloo, 2016-09-27)A series of fluorescently labeled vinyl polymers bearing a C1-C18 side-chain (namely poly(methyl methacrylate), poly(butyl methacrylate), poly(octyl methacrylate), poly(lauryl methacrylate), and poly(stearyl methacrylate) ... -
Long Range Polymer Chain Dynamics Studied by Fluorescence Quenching
(American Chemical Society, 2016-09-13)Over the years, fluorescence quenching experiments have provided a robust analytical means to retrieve information about the internal dynamics of macromolecules in general and the long range polymer chain dynamics (LRPCD) ... -
Long-Range, Polymer Chain Dynamics of a "Stiff" Polymer. Fluorescence from Poly(isobutylene-alt-maleic anhydride) with N-(1-Pyrenylmethyl)succinimide Groups
(American Chemical Society, 2017-04-25)The steady-state fluorescence (SSF) spectra and time resolved fluorescence (TRF) decays of five poly(isobutylene-alt-maleic anhydride) copolymers (PIMA), randomly labeled with N-(1-pyrenyl methyl)succinimide groups (Py-PIMA), ...