Browsing Chemistry by Author "Piccolo, Kyle"

Now showing items 1-2 of 2

Ligand Specificity and Affinity in the Sulforhodamine B Binding RNA Aptamer

Piccolo, Kyle; McNeil, Brooke; Crouse, Jeff; Lim, Su Ji; Hopkins, W. Scott; Dieckmann, Thorsten (Elsevier Inc., 2020-07-18)

Binding affinity and selectivity are critical properties of aptamers that must be optimized for any application. The sulforhodamine B binding RNA aptamer (SRB‐2) is a somewhat promiscuous aptamer that can bind ligands ...
Studying the Structure and Kinetics of Functional Nucleic Acids

Piccolo, Kyle (University of Waterloo, 2021-09-30)

Aptamers are valuable tools in a variety of biotechnological applications, ranging from biosensing to in vivo cell imaging. Studying these molecules can further our understanding of the structure and kinetics of nucleic ...