Browsing Chemistry by Author "Beriashvili, David"
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Action Mechanism and Structural Studies on the Lipopeptide Antibiotic Daptomycin
Beriashvili, David (University of Waterloo, 2019-07-02)Daptomycin (dap) is calcium-dependent lipopeptide antibiotic that is used clinically to treat systemic infections caused by Gram-positive pathogens. It is thought that dap brings about its antimicrobial effect by binding ... -
Mechanistic studies on the effect of membrane lipid acyl chain composition on daptomycin pore formation
Beriashvili, David; Taylor, Robert; Kralt, Braden; Abu Mazen, Nooran; Taylor, Scott D.; Palmer, Michael (Elsevier, 2018-11-01)Daptomycin is a lipopeptide antibiotic that binds and permeabilizes the cell membranes of Gram-positive bacteria. Membrane permeabilization requires both calcium and phosphatidylglycerol (PG) in the target membrane, and ...