Browsing Chemistry by Author "Kralt, Braden"
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Lipodepsipeptide Antibiotics: Total Synthesis and Mechanism of Action Studies Using 19F-NMR
Kralt, Braden (University of Waterloo, 2020-01-24)Daptomycin is a calcium-dependent cyclic lipodepsipeptide that is used clinically in the treatment of infections caused by pathogenic Gram-positive organisms, such as methicillin-resistant Staphylococcus aureus. Another ... -
Mechanistic studies on the effect of membrane lipid acyl chain composition on daptomycin pore formation
Beriashvili, David; Taylor, Robert; Kralt, Braden; Abu Mazen, Nooran; Taylor, Scott D.; Palmer, Michael (Elsevier, 2018-11-01)Daptomycin is a lipopeptide antibiotic that binds and permeabilizes the cell membranes of Gram-positive bacteria. Membrane permeabilization requires both calcium and phosphatidylglycerol (PG) in the target membrane, and ...