Browsing Science (Faculty of) by Subject "Daptomycin"
Now showing items 1-8 of 8
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Characterization of daptomycin oligomerization with perylene excimer fluorescence: Stoichiometric binding of phosphatidylglycerol triggers oligomer formation
(Elsevier, 2012-03)Daptomycin is a lipopeptide antibiotic that binds to and depolarizes bacterial cell membranes. Its antibacterial activity requires calcium and correlates with the content of phosphatidylglycerol in the target membrane. ... -
Estimation of the subunit stoichiometry of the membrane-associated daptomycin oligomer by FRET
(Elsevier, 2012-07)Daptomycin is a lipopeptide antibiotic that kills Gram-positive bacteria by depolarizing their cell membranes. This antibacterial action of daptomycin is correlated with the formation of membrane-associated oligomers. We ... -
Membrane binding and oligomer formation by the calcium-dependent lipopeptide antibiotic A54145: a quantitative study with pyrene excimer fluorescence
(Elsevier, 2016-09-20)A54145 is a lipopeptide antibiotic related to daptomycin that permeabilizes bacterial cell membranes. Its action requires both calcium and phosphatidylglycerol in the target membrane, and it is accompanied by the formation ... -
Mode of Action of Daptomycin, a Lipopeptide Antibiotic
(University of Waterloo, 2013-01-28)Daptomycin is a lipopeptide antibiotic that contains 13 amino acids and an N-terminally attached fatty acyl residue. The antibiotic kills Gram-positive bacteria by membrane depolarization. It has long been assumed that ... -
Molecular Dynamics Studies of Lipid Monolayer and Bilayer Systems
(University of Waterloo, 2016-08-02)Lipids are a crucial ingredient of biomembranes in cells, and they play a pivotal role in many chemical and biological processes. Lipid based structures, such as lipid monolayers and lipid bilayers, both natural and ... -
Mutual inhibition through hybrid oligomer formation of daptomycin and the semisynthetic lipopeptide antibiotic CB-182,462
(Elsevier, 2013-02)Daptomycin is a clinically important lipopeptide antibiotic that kills Gram-positive bacteria through membrane depolarization. Its activity requires calcium and the presence of phosphatidylglycerol in the target membrane. ... -
Photoaffinity Labels of Daptomycin
(University of Waterloo, 2014-05-23)Daptomycin (Dap) is a cyclic lipodepsipeptide antibiotic that is currently used in the treatment of bacterial infections caused by Staphylococcus aureus including the strains that are methicillin-resistant (MRSA), as well ... -
Structure-Activity Relationship Studies on Daptomycin
(University of Waterloo, 2018-08-22)Daptomycin (Dap) is a Ca2+-dependent cyclic lipodepsipeptide antibiotic used for treating skin infections caused by Gram-positive pathogens. It is also used to treat endocarditis caused by Staphylococcus aureus including ...