Browsing Science (Faculty of) by Supervisor "Spafford, David"
Now showing items 1-3 of 3
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Cloning and characterization of voltage-gated sodium and calcium channel homologs from the single-cell choanoflagellate, Salpingoeca rosetta
(University of Waterloo, 2016-12-15)We have isolated a complement of gene homologs from the simplest extant eukaryotic species to possess voltage-gated sodium (Na+) and calcium (Ca2+) channels, Salpingoeca rosetta. The isolated channels share the same 4 ... -
The Role of Domain II and Domain IV Extracellular Turrets in Determining Ion Selectivity in the T-type Calcium Channel from Lymnaea stagnalis
(University of Waterloo, 2016-07-20)The T-type calcium channel from the pond snail Lymnaea stagnalis, LCav3, undergoes alternative splicing in exon 12. Exon 12 codes for the L5 structure (S5-P) in Domain II (DII), which is dubbed the "turret". The turret is ... -
The role of sodium and calcium permeable T-type channels in generating pacemaking currents in invertebrates
(University of Waterloo, 2016-09-27)T-type calcium channels (Cav3) play a key role in generating rhythmic action potentials in excitable cells such as the heart pacemaker and sleep-wake cycles in the thalamus. T-type channels are low voltage-activated ...