Browsing Science (Faculty of) by Subject "obesity"
Now showing items 1-5 of 5
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An Assessment of Pyridoxine as a Biological Response Modifier During Colon Carcinogenesis
(University of Waterloo, 2007-10-05)The main objective of this proposal was to investigate the effect of vitamin B6 on colon carcinogenesis in vivo. Two in vivo studies were conducted to determine the role of vitamin B6 as a biological modifier of colon ... -
Assessment of the cell cycle proteins Cdc7 and PCNA as markers of colon carcinogenesis in obese and lean rats
(University of Waterloo, 2009-11-23)Obesity increases the risk of colon cancer as well as the expression of many cancer markers, ostensibly due to the interaction between insulin resistance and adipocyte production of hormones, mitogens and cytokines which ... -
IN VIVO EPIGENETIC STUDY OF HISTONE ACETYLATION ASSOCIATED WITH OBESITY
(University of Waterloo, 2007-10-02)Post translational modifications in histone proteins are transmissible changes that are not coded for in the DNA sequence itself but have a significant affect in the control of gene expression. Eukaryotic transcription is ... -
Modeling of Body Weight Metrics for Effective and Cost-Efficient Conventional Factor VIII Dosing in Hemophilia A Prophylaxis
(MDPI, 2017-12-01)The total body weight-based dosing strategy currently used in the prophylactic treatment of hemophilia A may not be appropriate for all populations. The assumptions that guide weight-based dosing are not valid in overweight ... -
Obesity associated colon tumorigenesis: An assessment of tumor phenotype
(University of Waterloo, 2006)Colon cancer and obesity are two significant and related pathological states with multiple etiological factors. In this dissertation, it was hypothesized that tumor growth is accelerated in the altered state of obesity ...