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Browsing Science (Faculty of) by Subject "S-phase checkpoint"
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Characterization of the association of Dbf4 and Cdc7 with Mcm2-7 and chromatin in Saccharomyces cerevisiae. (University of Waterloo, 2012-01-03)Initiation of DNA replication requires the action of the Dbf4/Cdc7 kinase complex (DDK) which is also a phosphorylation target of Rad53 kinase in the S-phase checkpoint. DDK is thought to trigger DNA replication by ...
Characterizing the Associations and Roles of DDK and Mcm2-7 DNA Replication Proteins in Saccharomyces Cerevisiae (University of Waterloo, 2014-05-21)The essential cell cycle kinase Dbf4/Cdc7 (DDK) triggers DNA replication through phosphorylation of the Mcm2-7 helicase at replication origins. Prior work has implicated various Mcm2-7 subunits as targets of DDK, however ...